328 mu M) and NTPDase3 (K(i) 2.22 mu M). Its isomer, 1-amino-2-sulfo-4-(1-naphthylamino)anthraquinone (20), was a potent and selective inhibitor of rat NTPDase3 (K(i) 1.5 mu M).”
“Objective: To evaluate periodontal condition of diabetic children and its related factors. Methods The plaque index (PI), sites with bleeding on probing (BOP), probing depth (PD) and clinical attachment level (CAL) were evaluated in all occlusion permanent teeth of 168 non smoking type 1 diabetic children, 13 +/- 3.5 years old. The PI and BOP evaluations were also performed in deciduous teeth. Results: It was

observed a prevalence of 20.8% of gingivitis and 5.9% of periodontis. Those individuals with poor metabolic control had higher percentage of affected sites on PARP signaling PD (p = 0.004) and on CAL (p = 0.014). Patients having selleckchem more than five years with diabetes mellitus type 1 showed higher percentual of affected sites on PD (p = 0.002), on BOP (p < 0.001) and on CAL (p = 0.007). Conclusions: DM1

duration and poor glycemic control were significantly associated with periodontal disturbances suggesting higher susceptibility of this population in developing DP Arq Bras Endocrinol Metab. 2009;53(3):348-54.”
“Background: Atrophic epithelium of cervix sampled from postmenopausal women may mimic high-grade cervical intraepithelial neoplasia in Papanicolaou-stained (Pap) smears. Ki-67 (MIB-1) protein

presents on proliferating cells, and percentage of cells with positive nuclei provides a reliable tool for rapid evaluation of the growth fraction. The aim of this PD-1/PD-L1 Inhibitor 3 mw study was to determine the diagnostic value of protein Ki67 staining in atypical pap smears of postmenopausal women. Methods: In a case-control setting, pap smears of 75 women with an atypical pap smear (case group) and 75 with normal pap smears (controls) were obtained before and after estrogen treatment. Afterward, samples were exposed to the monoclonal antibody Ki-67 (MIB-1) and the immunohistochemically demonstrated Ki-67+ cells were compared. Results: Mean ages of cases and controls were 60.4 +/- 4.5 and 59.9 +/- 4.3 years respectively (P=0.50). There was one (2.7%) positive Ki-67 specimen in the case group, without any positive Ki-67 specimen in the control group (P=0.50). Conclusions: Measurement of proliferative activity index in Pap smears restrained with MIB1 is a simple, reliable, and cost-effective method for excluding negatives. This would imply that it might allow a substantial reduction of diagnostic estrogen courses and subsequent Pap smears in postmenopausal women with atypical findings.”
“Multiple sclerosis (MS) is a common disabling autoimmune disease without an effective treatment in young adults.

Ecm is involved in the central reaction sequence of this novel pathway and catalyzes the transformation of ethylmalonyl-CoA to methylsuccinyl-CoA in combination with a second enzyme that was further identified as promiscuous ethylmalonyl-CoA/methylmalonyl-CoA epimerase. In contrast to the epimerase, Ecm is highly specific for its substrate, ethylmalonyl-CoA, and accepts methylmalonyl-CoA only at 0.2% relative activity. Sequence analysis revealed that Ecm is distinct from (2R)-methylmalonylCoA mutase as well as isobutyryl-CoA mutase and defines a new subfamily www.selleckchem.com/products/MLN8237.html of coenzyme B-12-dependent acyl-CoA mutases. In combination with molecular

modeling, two signature sequences were identified that presumably

https://www.selleckchem.com/products/i-bet-762.html contribute to the substrate specificity of these enzymes.”
“Purpose of review\n\nGastrointestinal affect human health and well being. The pathogens profoundly provider’s ability to render optimal care often highly depends on diagnostic microbiologic support. We aim to provide a clinically pertinent assessment of the current state of our ability to diagnose human gastrointestinal pathogens and describe (and decry) the unsophistication of many current diagnostic methods and strategies.\n\nRecent findings\n\nRecent advances involve improved stool polymerase chain reaction assays and application of this technology to a broader panel of pathogens, stool antigen assays, and improved culture techniques, but there is little penetration of such diagnostic advances into clinical practice. Many such techniques remain limited to research or epidemiologic use and are not typically available in the clinical laboratory.\n\nSummary\n\nMultiple clinical and laboratory factors need to be considered when attempting to diagnose the wide variety of gastrointestinal

pathogens afflicting humans. Careful interpretation of diagnostic tests with attention to the population studied and the characteristics of each test is necessary.”
“To investigate the total selleck inhibitor antioxidant status (TAS) and the extent of oxidative DNA damage in total lymphocytes and their relation with essential hypertension. A total of 130 South Indian subjects aged 30-65 were recruited for the study. Of these hypertensive subjects investigated, 30 were newly diagnosed and were not on any antihypertensive drugs, but had systolic blood pressure (BP) ranging between 140 and 160 mm Hg and diastolic BP between 95 and 100 mm Hg; 50 hypertensive patients who were already on drug therapy for 1 year and 50 were normotensive controls with BP p120/80 mm Hg. DNA damage was significantly increased in hypertensive patients (both newly diagnosed and who were already on drug therapy) compared with control group. The major increase in DNA damage was observed in newly diagnosed hypertensive patients compared with hypertensive patients who were already on drug therapy.

(C) 2012 Elsevier B.V. All rights reserved.”
“Twenty-five Bacillus strains capable of producing gamma-polyglutamic acid (PGA) were isolated from fermented locust bean products manufactured in the savanna area of

Ghana. To clarify the phylogeny of these PGA-producing strains, phylogenetic analyses based on sequences of 16S rDNA, rpoB (RNA polymerase P-subunit) and fus (elongation factor G) genes selleck chemicals llc were performed. A phylogenetic tree based on 16S rDNA indicated that ten isolates were clustered in the same group of Bacillus subtilis. Another ten isolates were located in the cluster of B. amyloliquefaciens, and the remaining isolates were identified as B. pumilus (three isolates) and B. licheniformis (two isolates), respectively. Phylogenetic trees based on the partial sequences of rpoB and fus genes were similar www.selleckchem.com/products/Nutlin-3.html to the phylogeny based on 16S rDNA sequences. Thirty-four strains in 27 species belonging to the genus Bacillus and its neighbors were also investigated for PGA production. It was found that PGA was produced by B. amyloliquefaciens NBRC 14141 and NBRC 15535(T),

B. atrophaeus NBRC 15539(T), B. licheniformis NBRC 12107, B. mojavensis NBRC 1571 8(T), B. pumilus NBRC 12094, B. subtilis NBRC 16449, and Lysinibacillus sphaericus NBRC 3525. Except for L. sphaericus, the above Bacillus species are very closely related in phylogeny, indicating that PGA-producing Bacillus strains constitute a cluster.”
“The mechanisms of abnormal high pressures are studied in this paper, and it is concluded that the undercompaction, hydrocarbon generation and stratum denudation are obviously effective to fluid pressure buildup. Because of the episodic difference, the hydrocarbon generation and stratum denudation are the main factors influencing https://www.selleckchem.com/products/MK-2206.html oil-gas migration. On the basis of basin evolutionary analysis in the Dongying Sag, it is considered that the undercompaction mainly caused the abnormal pressure before the first denudation by the uplift

in Late Paleogene, while hydrocarbon generation was the main factor of abnormal pressure after the denudation. The second denudation occurred in Late Neogene, which changed the pressure field and induced the fluid migration. The development of overpressures is the necessary condition to the formation of lithologic hydrocarbon reservoirs, which have positive correlations to overpressures. According to the fullness of the present reservoirs, the quantitative relations between oil-bearing property and driving forces of reservoir formation were determined, the latter were decided by dynamic source, reservoir capillary pressure, fluid pressure of surrounding rocks and the dynamic attenuation in different conducting systems.”
“Hepatitis B virus infection is a major public health problem worldwide. Islamic Republic of Iran is a Country in which hepatitis B prevalence is intermediate.

CONCLUSIONS: In young patients, colorectal liver metastases seem to be more aggressive, with a trend toward lower OS, more disease recurrences, and a significantly shorter PFS after hepatectomy. However, DFS rates were comparable between young and older patients, owing to an aggressive multimodality treatment approach, consisting of chemotherapy and repeat surgery. Therefore, physicians should recognize the poor outcome of colorectal liver metastases in young patients and should consider an

aggressive approach to diagnosis and early treatment. Cancer P005091 datasheet 2010;116:647-58.(C) 2009 American Cancer Society.”
“Two-stage designs offer substantial advantages for early phase II studies. The interim analysis following the first stage allows the

study to he stopped for futility, or more positively, it might lead to early progression to the trials needed for late phase H and phase III. If the study is to continue to its second stage, then there is an opportunity for a revision of the total sample size. Two-stage designs have been implemented widely in oncology LY294002 inhibitor studies in which there is a single treatment arm and patient responses are binary. In this paper the case of two-arm comparative studies in which responses are quantitative is considered. This setting is common in therapeutic areas other than oncology. It will be assumed that observations are normally distributed, but that there is some doubt concerning their standard deviation, motivating the need for sample size review. The work reported has been motivated by a study in diabetic neuropathic pain, and the development HDAC inhibitor of the design for that trial is described in detail. Copyright (C) 2008 John Wiley & Sons, Ltd.”
“There is indicative epidemiological evidence that exposures of children

younger than about 10 years are linked with an increased risk of the development of malignant melanoma as well as non-melanocytic skin cancers later in life. However, an important area of uncertainty relates to lack of knowledge of the sun-sensitivity of children’s skin both absolutely and relative to that of adult’s skin. For example the thickness of children’s skin is very similar to that of adults but due to the nature of the anatomical structure of children’s skin, there are indications of children’s skin being adversely exposed on the top of the papilla before a significant exposure manifests itself as visible damage to the skin (for example erythema). This might also affect the induction of heavily UV-damaged cells persisting in the basal layer of the epidermis after UV-exposure which are supposed to be keratinocytic epidermal stem cells and may characterize an initiation step of non-melanoncytic skin cancer. For malignant melanoma the number of nevi received in dependence of UV-exposure in childhood is a clear risk factor.

It is therefore critical to determine the optimal surgical treatment during the initial courses of chemotherapy. Patients with PRETEXT IV tumors, multifocal tumors and tumors invading major vessels of the liver are candidates for liver transplantation. Liver transplantation requires preparation in advance, and consultation to a liver expertise team must take place no later than

after two cycles of chemotherapy. The existence of pulmonary metastasis is a predictor of poor prognosis of the patient. Surgery for pulmonary nodules should be considered for those patients remaining Compound C mouse positive after cycles of chemotherapy. A considerable number of patients have been reported to achieve long-term survival after resecting

pulmonary metastasis. The existence of pulmonary metastasis at diagnosis is no longer a contraindication for liver transplantation, provided that the pulmonary nodules are eliminated by chemotherapy or by metastasectomy. Transcatheter arterial chemoembolization (TACE) is a useful tool for the local control of hepatoblastomas, PI3K inhibitor although there are very few reports statistically supporting the significant advantage of this treatment modality. Based on individual cases, TACE could be beneficial in maximizing the anti-tumor effect with less toxic side effects.”
“A Gram-positive, aerobic actinobacterium with high chromate [Cr(VI]-reducing ability, designated strain Q5-1(T), was isolated from manganese mining soil in Hunan Province, central-south China. The organism formed branching hyphae and contained LL-diaminopimelic acid in the cell-wall peptidoglycan. The polar lipid profile was characterized LY2157299 by diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol, phosphatidylinositol mannoside and an unidentified phospholipid. The major fatty acids were iso-C-14:0, iso-C-15:0,

anteiso-C-15:0 and iso-C-16:0, and the predominant menaquinone was MK-8(H-4). The genomic DNA G+C content was 71.5 mol%. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain Q5-1(T) was closely related to Intrasporangium calvum DSM 43043(T) (=NRRL B-3866(T)) and Humihabitans oryzae KV-657(T) (=NRRL B-24470(T)) with similarities of 96.6 and 96.4 %, respectively. Comparison of phenotypic, biochemical and chemotaxonomic characters of strain Q5-1(T) and phylogenetically related strains revealed that the isolate represents a novel species of the genus lntrasporangium, for which the name lntrasporangium chromatireducens sp. nov. is proposed. The type strain is Q5-1(T) (=KCTC 19811(T)=CCTCC AA 2010019(T)=CGMCC 1.10750(T)=NRRL B-59521(T)). An emended description of the genus lntrasporangium is also proposed.”
“A C-type lectin-like protein (Ec-CTLP) was cloned from the grouper Epinephelus coioides. The full-length cDNA of Ec-CTLP was composed of 905 bp with a 522 bp open reading frame that encodes a 174-residue protein.

The samples were then eroded by citric acid (pH 2.6) for 5 days (6×1 Bcl-xL protein min daily). Erosive substance loss, surface topographic and compositional changes were investigated using surface profilometry, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS), respectively, after fluoride pretreatment and after erosion. The results indicate high-concentrated AmF solution at native pH was effective in inhibiting erosion in the conventional glass-ionomer cement and polyacid-modified resin composite.”
“Current research in psychology suggests that unconscious processes influence a significant proportion of choices

and decisions. To study the impact of a non-attentively perceived odour on food choices, we used a priming paradigm. We had previously shown that non-attentively perceived fruity odours could impact food choice intentions (on a menu card), guiding participants toward items containing more fruit and/or vegetables. The present study was designed to extend these findings, in a real-life consumption setting. One hundred and fifteen participants took part in this study, and were assigned randomly to either a control or a scented condition. On arrival in the laboratmy, they were seated in a waiting

room. For the scented condition, they were unobtrusively exposed to a pear odour, while under the control condition the waiting room was non-odorised. Following this waiting period, all participants moved into a non-odorised test room where they were asked to choose, from dishes served buffet-style, the starter, main course

and dessert that they would actually eat for lunch. The results showed GDC-0994 that participants subjected to the scented condition chose to consume the ‘fruity’ dessert (compote) more frequently than those who had waited under the control condition, who chose more frequently the dessert without fruit (brownie). In line with the findings of our previous study, these results confirm the idea of priming effects ‘specific to the food cue’. To conclude, a non-attentively perceived fruity BEZ235 manufacturer odour was shown to influence actual food choices, guiding individuals towards more fruity desserts. The involvement of implicit processes in food choices should be taken into account in guidelines and strategies designed to promote healthy eating. (C) 2014 Elsevier Ltd. All rights reserved.”
“Direct composite resin layering techniques preserve sound tooth structure and improve function and esthetics. However, intraoral placement techniques present challenges involving isolation, contamination, individual patient characteristics, and the predictability of restorative outcomes. Computer-aided design and computer-aided manufacturing (CAD/CAM) restorations enable dentists to better handle these variables and provide durable restorations in an efficient and timely manner; however, milled restorations may appear monochromatic and lack proper esthetic characteristics.

Herein, we evaluate if gender has an impact on outcomes after modern off-pump coronary artery bypass grafting (OPCAB). From 2002 to 2007, we analyzed

983 patients (male: n=807/female: n=176) who underwent OPCAB with symptomatic multi-vessel disease find more at our institution. The link between gender and outcome was assessed by multivariate analysis and logistic regression. A composite endpoint was constructed from: 30-day-mortality, renal failure, prolonged intensive care unit (ICU) stay, neurological complications, use of intra-aortic balloon pump (IABP) and conversion to CPB. Mortality was 3.2% in women vs. 1.8% in men (P=0.15) and the EuroSCORE was significantly correlated to gender (6.8 vs. 5.2; P<0.001), even after correction (P=0.036). Significant more occurrence of the composite endpoint was noted in women (39.8% vs. 29.0%; P=0.007) whereas for men the risk was much lower [odds ratio (OR) 0.65; 95% confidence interval (CI) 0.46-0.92; P=0.015]. For both genders the logistic regression revealed a risk increase of

15% per one-point-increase of EuroSCORE (corrected) (OR 1.15; 95% CI: 1.10-1.19; P<0.0001). Women had more frequently a prolonged stay at ICU (P=0.006) and had a higher stroke rate (2.3% vs. 1.2%; P=0.29). Complete revascularization was achieved similarly (95% vs. 94%; P=0.93). OPCAB offers low mortality and excellent clinical outcome. FK506 Women are more likely to experience postoperative complications. Even if partially neutralized by avoiding CPB, gender differences

remain present with modern OPCAB strategies. (C) 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.”
“Objective. To investigate the associations of 25-(OH) D and beta-cell function or insulin resistance or albuminuria in Chinese type 2 diabetic patients. Methods. In total, 1408 type 2 diabetic patients without vitamin D supplement were included in this retrospective study. Results. Comparison between patients with and without 25-(OH) D deficiency indicated that, compared with patients with 25-(OH) D bigger than = 50 nmol/L, patients Selleck HDAC inhibitor with 25-(OH) D smaller than 50 nmol/L showed a higher level of urine albumin-creatinine ratio (ACR) (90.15 +/- 10.30 mg/g versus 52.79 +/- 14.97mg/g). Multiple regression analysis indicated that 25-(OH) D was independently and negatively correlated with urine ACR (OR = 0.985, 95% CI 0.972-0.999, P = 0.03), adjusted by age, diabetic duration, HBP duration, SBP, HbA1c, creatinine, LDL-C, triglyceride, total cholesterol, and HDL-C. Compared with patients with normal level of urine ACR, patients with higher level of urine ACR showed a significant lower level of 25-(OH) D (34.49 +/- 13.52 nmol/L versus 37.46 +/- 13.6 nmol/L, P = 0.00).

“
“Arsenic (As) mobilization

in alluvial aquifers is caused by a complex interplay of hydro-geo-microbiological activities. Nevertheless, diversity and biogeochemical significance of indigenous bacteria in Bengal Delta Plain are not well documented. We have deciphered bacterial community compositions and metabolic properties in As contaminated groundwater BIBF 1120 molecular weight of West Bengal to define their role in As mobilization. Groundwater samples showed characteristic high As, low organic carbon and reducing property. Culture-independent and -dependent analyses revealed presence of diverse, yet near consistent community composition mostly represented by genera Pseudomonas, Flavobacterium, Brevundimonas, Polaromonas, Rhodococcus, Methyloversatilis and Methylotenera. Along with As-resistance and -reductase activities, abilities to metabolize a wide range carbon substrates including long chain and polyaromatic hydrocarbons and HCO3, As3+ as electron donor and As5+/Fe3+ as terminal electron

acceptor during anaerobic growth were frequently observed within the cultivable bacteria. Genes encoding cytosolic As5+ reductase (arsC) and As3+ efflux/transporter [arsB and acr3(2)] were found to be more abundant than the dissimilatory As5+ reductase gene arrA. The observed metabolic Galardin in vitro characteristics showed a good agreement with the same derived from phylogenetic lineages of constituent populations. Selected bacterial strains incubated anaerobically over 300 days using natural orange sand of Pleistocene aquifer showed release of soluble As mostly as As3+ along with several other elements (Al, Fe, Mn, K, etc.). Together with the production of oxalic acid within the biotic microcosms, change buy VX-770 in sediment composition and mineralogy indicated dissolution of orange sand coupled with As/Fe

reduction. Presence of arsC gene, As5+ reductase activity and oxalic acid production by the bacteria were found to be closely related to their ability to mobilize sediment bound As. Overall observations suggest that indigenous bacteria in oligotrophic groundwater possess adequate catabolic ability to mobilize As by a cascade of reactions, mostly linked to bacterial necessity for essential nutrients and detoxification.”
“Extrinsic cues and intrinsic competence act in concert for cell fate determination in the developing vertebrate retina. However, what controls competence and how precise is the control are largely unknown. We studied the regulation of competence by examining the order in which individual retinal progenitor cells (RPCs) generate daughters. Experiments were performed in Xenopus laevis, whose full complement of retinal cells is formed in 2 days. We lineage-labeled RPCs at the optic vesicle stage. Subsequently we administered a cell cycle marker, 5-bromodeoxyuridine (BrdU) at early, middle or late periods of retinogenesis.

(C) 2010 Elsevier B.V. All rights reserved.”
“The aim of this study was to investigate the activation of JNK1/2 signalling pathway and the respective cellular phenotype of H9c2 cardiac myoblasts during two distinct types of oxidative insult. We examined the dose- and time-dependent activation of JNK1/2 pathway by exogenous H2O2, both under transient and sustained stimulation. At 2 h of either sustained or transient treatment, learn more maximal phosphorylation of c-Jun was observed, coincidently with the activation of nuclear JNK1/2; under sustained stress, these phosphorylation levels remained elevated above basal

for up to 6 h, whereas under transient stress they declined to basal ones within 4 h of withdrawal. Furthermore, the JNK1/2 selective inhibitor SP600125 abolished the c-jun phosphorylation induced by oxidative stress. Our results using cell viability assays and light microscopy revealed that sustained H2O2 stimulation significantly and time-dependently decreased H9c2 viability, in contrast to

transient stimulation; SP600125 (10 mu M) abolished cell death induced by sustained as well as cell survival induced by transient oxidative stress. Hoechst staining showed an increase in DNA condensation during sustained, but not during transient stimulation. Moreover, from the antioxidants tested, catalase and superoxide dismutase prevented oxidative stress-induced cell death. Flow cytometry studies reconfirmed that sustained oxidative stress induced apoptosis, whereas Combretastatin A4 order transient resulted in the recovery of cardiac myoblasts within 24 h. We conclude

that in H9c2 myoblasts, sustained activation of JNK1/2 signalling pathway during oxidative stimulation is followed by an apoptotic phenotype, while transient JNK1/2 activation correlates well with cell survival, suggesting a dual role of this signalling pathway in cell fate determination.”
“Left Atrial Stiffness and Atrial Fibrillation. Introduction: An increased left atrial (LA) stiffness reflects the structural remodeling and deterioration of the LA function. This study was designed to estimate LA stiffness by measuring a combination of the strain and LA pressure in patients undergoing pulmonary vein isolation GPCR Compound Library (PVI) of atrial fibrillation (AF) and to evaluate the influence of the LA stiffness on the cardiac function, serum markers, and recurrence of AF after PVI.\n\nMethods: In 155 consecutive patients with AF, the brain natriuretic peptide (BNP) and aminoterminal procollagen type III propeptide (PIIIP) plasma levels were measured before the PVI. The difference between the minimum and maximum LA systolic pressures was directly measured by a transseptal puncture. The ratio of the difference in the LA pressures to the peak systolic LA strain evaluated by speckle-tracking echocardiography was used as an index of the LA stiffness.

(C) 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.”
“Persisting Symptoms after Elective Sigmoid Resection for Sigmoid Diverticulitis\n\nIn the past, sigmoid resection in patients with recurrent sigmoid diverticulitis was typically recommended after the second episode. In recent years, this practice has been questioned as well as abandoned in favor of a more individual decision making. After elective sigmoid resection for diverticulitis, however, approximately a quarter of all patients report persistent or new-onset symptoms. In the minority of cases, see more actually genuine recurrent diverticulitis plays a role,

in which the height of the anastomosis is a determining factor. Often patients report about symptoms suggestive of irritable bowel syndrome, and studies in the recent years also show an overlap of

irritable bowel syndrome and diverticular disease. Recent studies suggest that visceral hypersensitivity and markers SRT2104 of inflammation are correlated in patients with symptomatic diverticular disease. In conjunction with predisposing factors such as obesity, these conditions may be a key reason for persistent complaints. Therefore, on the one hand, it will be up to the physician to identify those patients who are at high risk for complications and have a high probability of remaining symptom-free postoperatively. On the other hand, patients who will selleck screening library most likely not benefit from surgery should be directed towards other treatment modalities.”
“Background: Bovine cutaneous fibropapillomas are benign hyperproliferative lesions induced by Bovine Papillomaviruses (BPVs). Bcl-2 is an important anti-apoptotic protein which is expressed in several cancer types. In contrary, p53 is a tumour suppressor protein that mediates cell cycle arrest, apoptosis and senescence in response to cellular stresses. Findings: Here, we investigated immunohistochemically and biochemically, the expression

of bcl-2 and p53 in a subset of BPV positive fibropapillomas and bovine normal skin. Normal skin samples showed a weak signal for both proteins in the cytoplasm of the basal cells. Nine out of twelve (75%) tumour samples stained positive for bcl-2 throughout basal and parabasal layers, with most of cells showing strong cytoplasmic immunoreactivity. Nine out of twelve (75%) fibropapillomas were found to be positive for p53 expression, showing a strong cytoplasmic and perinuclear staining of p53 protein mainly in the basal and parabasal layers. Conclusions: Our data reveal an altered bcl-2 and p53 immunoreactivity in bovine cutaneous fibropapillomas, suggesting involvement of these two proteins in the cutaneous neoplastic transformation through an impaired apoptotic process.”
“Aim This study aimed to compare the effect of extended margin and conventional bleaching trays on tooth bleaching and tooth sensitivity.