Results were analysed and represented graphically using Microsoft Office Excel 2007. Ethics approval was not required. Forty patients were included, 62.5% were males with a mean age of 43 years. Each time a biologic agent was started, it was analysed as a separate entry. This increased the perceived number of patients on biologics to 52. Standard
Aim (%) Result (%) Comments Topical therapy offered initially as first line treatment. 100 52.5 (21/40) - 19/40 information unknown Psoriasis had not responded, patient’s were intolerant or had a contraindication to the standard systemic therapies before initiation on a biologic therapy: a) PUVA Practitioner’s at King’s College Hospital were not complying to NICE guidelines.1 The inappropriate use of biologics could unecessarily expose patients to side effects and further the financial selleck chemicals llc strain on the NHS.2 However the validity of the data and extent of non-compliance
to the guidelines could not be fully assessed primarily due to poor documentation. Improvements in documentation with a pro forma may allow for more accurate evaulation. 1. NICE. Psoriasis. The assessment and management of psoriasis. NICE clinical guideline 153. [online] 2012. http://www.nice.org.uk/nicemedia/live/13938/61190/61190.pdf (accessed 22/11/13). 2. NICE. Commissioning biologic drugs for the treatment of inflammatory disease in rheumatology, dermatology and gastroenterology. [online] 2012 http://www.nice.org.uk/usingguidance/commissioningguides/biologicaltherapies/CommissioningBiologicDrugs.jsp (accessed 08/01/14). G. Randhawaa, L-C. Chena, T. Hillsb, www.selleckchem.com/products/Roscovitine.html R. Knaggsa,b, J. Tokarskia aUniversity of Nottingham, Nottingham, UK, bNottingham University Hospital NHS Trust, Nottingham, UK
Adherence to Trust vancomycin dosing guidelines needs to be evaluated. The adherence rate to loading and maintenance dosing guidance was 46.8%. The proportion of first pre-dose levels that reached therapeutic range for patients whose dosing was adherent or non-adherence to guideline was 61.1% vs. 53.7%. Guideline adherence increases the likelihood that the first pre-dose level reaching the therapeutic range. Vancomycin is an important antibiotic Flavopiridol (Alvocidib) in the treatment of serious bacterial infections, including methicillin-resistant Staphylococcus aureus. To quickly reach its best therapeutic onset level, a loading dose (LD) is recommended prior to a regular maintenance dose (MD). International guidelines have also recommended that a LD should be given to reach an optimal pre-dose level (PDL; the trough vancomycin blood level measured immediately before the fourth dose is administered) at 10–20 mg/L. Local vancomycin dosing guidelines were revised in July 2013 that recommended LD and MD according to a patient’s body weight and creatinine clearance, respectively. However, it is unclear whether this simple guideline is well followed.