In all cases, malolactic conversion was faster after yeast-bacter

In all cases, malolactic conversion was faster after yeast-bacterial co-inoculation and was completed in simultaneous treatments at pH values of 3.35-3.65, and consecutive treatments at pH 3.5 and 3.65. No statistically significant difference was observed among the final acetic acid concentrations among all inoculation and pH treatments, but there was a trend towards higher acetic acid residues in wines produced by co-inoculation, especially at high Anlotinib Protein Tyrosine Kinase inhibitor pH values. Overall,

simultaneous AF/MLF allowed for greatly reduced fermentation times, but the must pH remained a strong factor for fermentation success and determined the final concentration of various wine components. The time point of inoculation influenced formation and degradation kinetics of organic acids and acetaldehyde considerably, and these are of relevance for vinification decisions. Published by Elsevier Ltd.”
“Films of poly(3,4-ethylenedioxythiophene) were prepared with single and multiple electropolymerization steps, where the numbers of polymerization steps (n’s) were 3, 5, and 7, with identical experimental conditions and total polymerization times (tau’s). The electroactivity of the films prepared with multiple steps remained almost unaltered when n increased, with the ability of the films to store charge with n > 3 being

smaller than that of the films with similar thicknesses but derived from a single electrodeposition step. In contrast, STI571 mouse the stability of the films produced with n polymerization steps was significantly higher than that of the films derived from a single step with the same tau, with the difference between the two systems increasing with n, that is, tau used to yield the films. On the other hand, although the morphological and topological characteristics of the surface and the electrical conductivity were affected by the procedure used to produce the films, the organization of the polymer molecules in the crystalline phase, the thermal stability, and the electronic properties (ionization potential, electron affinity, and lowest pi-pi* transition energy) were practically identical in both cases.

(C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 121:1982-1991, 2011″
“Knotted GDC-0973 mouse proteins, because of their ability to fold reversibly in the same topologically entangled conformation, are the object of an increasing number of experimental and theoretical studies. The aim of the present investigation is to assess, on the basis of presently available structural data, the extent to which knotted proteins are isolated instances in sequence or structure space, and to use comparative schemes to understand whether specific protein segments can be associated to the occurrence of a knot in the native state. A significant sequence homology is found among a sizeable group of knotted and unknotted proteins. In this family, knotted members occupy a primary sub-branch of the phylogenetic tree and differ from unknotted ones only by additional loop segments.

The application

of a negative pressure is a novel approac

The application

of a negative pressure is a novel approach to severe abdominal sepsis and laparostomy management with a view to preventing compartment syndrome and fatal sepsis, and it can lead to complete abdominal wound closure.”
“Background: The Prexasertib aim of the present work was to assess the in vitro cross-resistance of pyronaridine with other quinoline drugs, artesunate and several other commonly used anti-malarials and to evaluate whether decreased susceptibility to pyronaridine could be associated with genetic polymorphisms in genes involved in reduced quinoline susceptibility, such as pfcrt, pfmdr1, pfmrp and pfnhe.

Methods: The in vitro chemosusceptibility profiles of 23 strains of Plasmodium falciparum were analysed by the standard 42-hour 3H-hypoxanthine uptake inhibition method for pyronaridine, artesunate, chloroquine, monodesethylamodiaquine, quinine, mefloquine, lumefantrine, atovaquone, pyrimethamine and doxycycline. Genotypes were assessed for pfcrt, pfmdr1, pfnhe-1 and pfmrp genes.

Results: The IC50 values for pyronaridine ranged from 15

to 49 nM (geometric mean = 23.1 nM). A significant positive correlation was found between responses to pyronaridine and responses to artesunate (r(2) = 0.20; P = 0.0317) but too low to suggest cross-resistance. No significant correlation was found between pyronaridine IC50 and responses to other anti-malarials. Significant associations were not found between pyronaridine IC50 and polymorphisms in pfcrt, pfmdr1, pfmrp or pfnhe-1.

Conclusion: There was an absence of cross-resistance FGFR inhibitor between pyronaridine and quinolines, and the IC50 values for pyronaridine were found to be unrelated to mutations in the transport protein genes pfcrt, pfmdr1, pfmrp or pfnhe-1, known to be involved in quinoline resistance. These results confirm the interest and the efficacy of the use of a combination of pyronaridine and artesunate in areas in which parasites are resistant to quinolines.”
“Abnormalities in blood inflammatory

HIF-1 activation markers have been associated with clinical manifestations and the pathogenesis of the fibromyalgia syndrome (FMS); a relationship between inherited alpha1-antitrypsin deficiency (AATD) and FMS has also been recently raised. In this study, plasma levels of inflammatory markers in FMS patients with and without AATD have been investigated. Blood samples from 138 age-matched females (79 FMS) and 59 general population (GP), with normal MM [n = 82 (59.4%)] and with MS, MZ, SZ, and ZZ AATD genotypes [n = 56 (40.6%)], were analyzed by ELISA for monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF alpha), soluble TNF alpha receptors I and II, interleukin-8, and vascular endothelial growth factor (VEGF).

We present a case of a rare intravascular large T-cell lymphoma i

We present a case of a rare intravascular large T-cell lymphoma in a 59-year-old man with an unusual CD3(+), CD4(+), CD5(-), CD30(+), CD56(-), TIA-1-negative and EBER-negative phenotype. This T Selleck LY333531 helper or CD30(+) phenotype is particularly uncommon. To our knowledge, it has only been described once before and never in the absence of the cytotoxic marker TIA-1. This case exemplifies the particular diagnostic challenges raised by intravascular large cell lymphomas generally and should encourage the use of endothelial immunohistochemical

staining in questionable cases. While evaluating skin punch biopsies, it is critical to keep this rare entity on the differential diagnosis along with the relatively more common intravascular large B-cell lymphoma and epithelial malignancies. Additionally, our understanding of intravascular

large natural killer/T-cell lymphoma as a heterogeneous phenotypic entity continues to evolve. This case demonstrates that the degree of this phenotypic heterogeneity may be even greater than selleck screening library previously thought.”
“Objectives: This in vivo study was carried out to assess the influence of the operator experience on the survival rate of proximal-ART restorations using a two-layer technique to insert the glass-ionomer cement (GIC).

Study Design: Forty five proximal cavities in Selleckchem ATM Kinase Inhibitor primary molars were restored in a school setting according to the ART technique. The cavities were restored by two operators with Ketac Molar Easymix, and received a flowable layer of GIC prior to a second GIC layer with a regular consistency. The operators had different clinical experiences with ART (no experience or two years of experience), but both completed a one-week training to perform the restorations and the GIC mixing in this study.

Results: After a 12-month follow-up, 74% of the restorations survived; the main reason for failure was bulk fracture or total loss of the restoration. There was no operator influence (log-rank test p=0.2)

Conclusion: The results encourage

future well designed controlled clinical trials using the two-layer technique for insertion of GIC in proximal-ART restorations, after training the operators.”
“Purpose: The EGFR tyrosine kinase inhibitors (TKIs) demonstrate efficacy in NSCLC patients whose tumors harbor activating EGFR mutations. However, patients who initially respond to EGFR TKI treatment invariably develop resistance to the drugs. Known mechanisms account for approximately 70% of native and acquired EGFR TKI resistance. In the current study we investigated a novel mechanism of NSCLC resistance to erlotinib. Experimental Design: The mechanisms of acquired erlotinib resistance were evaluated by microarray analysis in thirteen NSCLC cell lines and in vivo in mice.

05)

Conclusions: The findings of our study demonstrat

05).

Conclusions: The findings of our study demonstrated a possible association between the self-insertion of nasal and aural foreign FDA-approved Drug Library cell line bodies and ADHD. Clinicians should be aware of the possible presence of ADHD in children, especially in those patients between 5 and 9 years of age who present with self-inserted nasal and aural foreign bodies. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“There are few studies on sedation medication requirements and sedation related adverse events in developmentally disabled children.

The objectives of our study were to compare sedation medication received and sedation

related adverse events for brain magnetic resonance imaging (MRI) between children with and without developmental disabilities. We hypothesized that developmentally disabled children would require increased doses of sedative medications and will have increased frequency of adverse events when compared with normal children.

We conducted a retrospective AZD8931 concentration chart review on children 1-18 years, who required sedation for an elective brain MRI. Children were excluded if they required sedation for diagnostic imaging other than brain MRI, belonged to ASA category > 3, or required general anesthesia. Data on developmental

status, demographics and details of sedation medications received along with adverse events were collected.

About 53.5% (260/486) of the patients were classified as developmentally disabled. Pentobarbital and fentanyl were the two most common medications used for sedation in children with and without developmental disability. There was no difference in the mean dosages of pentobarbital (3.02 mg.kg(-1) vs 3.06 mg.kg(-1); P = 0.2) and fentanyl (1.01 mcg.kg(-1) vs 1.02 mcg.kg(-1); P = 0.81) in the two groups. There buy MK-0518 was

a threefold increased incidence of hypoxia noted in children with developmental disability (11.9% vs 4.9%; P < 0.01). Presence of developmental disability alone was significantly associated with sedation related hypoxia (OR = 3.2, 95% CI: 1.8, 6.94; P < 0.01).

Children with developmental disabilities have similar requirements for sedation medications but are three times more likely to experience hypoxia when compared with normal children.”
“Rifabutin loaded floating gellan gum beads were prepared by Ca(++) induced ionotropic gelation in acidic medium by drop wise addition of gellan gum dispersion containing drug and gas-generating agent. The prepared beads were evaluated for in vitro characterization and in vivo Helicobacter pylori clearance efficiency following repeated oral administration to H. pylori infected albino rats. Live cell staining of stomach homogenates of H. pylori infected animals treated with rifabutin showed pronounced anti H. pylori activity.


“We have demonstrated the proof of principle of a semicond


“We have demonstrated the proof of principle of a semiconductor neuron, which has dendrites, axon, and a soma and computes information encoded in electrical pulses in the same way as biological neurons. Electrical impulses applied to dendrites diffuse along microwires to the soma. The soma is the active part of the neuron, which regenerates input pulses above a voltage threshold and transmits them into the axon. Our concept of neuron is a major step forward because

its spatial structure controls the timing NVP-AUY922 of pulses, which arrive at the soma. Dendrites and axon act as transmission delay lines, which modify the information, coded in the timing of pulses. We have finally shown that noise enhances the detection sensitivity of the neuron by helping the transmission of weak periodic signals. A maximum enhancement of signal transmission was observed at an optimum noise level known as stochastic resonance. The experimental results are in excellent agreement with simulations of the FitzHugh-Nagumo model. Our neuron is therefore extremely well suited to providing feedback on the various mathematical approximations of

neurons and building functional networks. (C) 2011 American Institute of Physics. [doi:10.1063/1.3577609]“
“In rheumatic patients candidate to anti-TNF-alpha HSP990 treatment, there is an increased risk of developing tuberculosis (TB). The tuberculin skin test (TST), the standard diagnostic test for latent tuberculosis infection (LTBI), suffers low specificity and sensitivity. Here, we compared the performance characteristics of an in-house ELISPOT-IFN-gamma assay (using a restricted pool of Mycobacterium tuberculosis-specific peptides or MTP) to TST for the diagnosis of LTBI in 69 rheumatic patients candidate to anti-TNF-alpha treatment and in 60 healthy LTBI individuals. Among the 69 patients enrolled, 17 (25%) had a positive TST response and 15 (22%) a positive ELISPOT-MTP response. Among the patients with a positive TST result, eight had a positive and nine a negative ELISPOT-MTP response, whereas among the 49 patients

with a negative TST result, 42 were ELISPOT-MTP negative, but seven (14%) were ELISPOT-MTP positive, with three indeterminate results. The agreement between the two tests was poor (k = 0.341, 95% CI = 0.060 to 0.622) and the test of symmetry was not SBC-115076 significant (P = 0.8). Considering the ELISPOT assay, rheumatic patients had a reduced number of spot-forming cells after stimulation of lymphocytes with PHA or PPD when compared with healthy LTBI individuals. Thus, the ELISPOT-IFN-gamma assay performs better than the TST in recognizing patients with LTBI, on one hand reducing the number of patients submitted to isoniazid prophylaxis, and on the other hand, since the assay is less biased by immunosuppressive regimens than TST, recognizing LTBI patients among those with a negative TST response.

The results of elemental analysis indicated that the N atoms were

The results of elemental analysis indicated that the N atoms were incorporated into the molecule of polymerized oil, which was pyrolyzed by pyrolysis gas chromatography with a mass selective detector to clarify the structure with nitrogen atoms. It was confirmed

that in the molecule of polymerized oil, there were three nitrogen heterocyclic compounds, which played a key role in improving the tribological characteristics of the polymerized oils. The lubricating properties of polymerized oils were performed on the four ball friction and wear testers. selleck chemicals The load-carrying capacities of polymerized oils reached 940.8 N and 1049 N, respectively, higher than that of soybean oil (646.8 N). Meanwhile, they showed better anti-wear properties under all tested loads and possessed preferable friction-reducing performances when the applied load surpassed 250 N. The friction surfaces lubricated by soybean oil and polymerized

oil were observed by a scanning electron microscope (SEM), and the chemical states and compositions of the tribofilms generated during the rubbing DZNeP datasheet process were analyzed by X-ray photoelectron spectroscopy (XPS). It was found that the nitrogen heterocyclic structure containing six N atoms possessed higher coordination capacity than the ester groups of soybean oil, and could form a durable organic nitrogen complex film on the metal surface. Simultaneously, the blended oils with different viscosity grades, which were prepared by diluting the polymerized oil with dioctyl sebacate, showed excellent receptivity on the anti-wear/extreme pressure additives of zinc dialkyl buy CT99021 dithiophosphates and sulfurized isobutylene. (C) 2013 Elsevier B.V. All rights reserved.”
“Background: Late gadolinium enhancement (LGE) is identified frequently in LVNC. However, the features of this findings are limited. The purpose of the present study was to describe the frequency and distribution of LGE in patients meeting criteria for left ventricular non-compaction (LVNC), as assessed by cardiovascular magnetic resonance (CMR).

Methods: Forty-seven patients

(37 males and 10 females; mean age, 39 +/- 18 years) considered to meet standard CMR criteria for LVNC were studied. The LGE images were obtained 15 +/- 5 min after the injection of 0.2 mmol/kg of gadolinium-DTPA using an inversion-recovery sequence, and analyzed using a 17-segment model.

Results: Mean number of non-compacted segments per patient was 7.4 +/- 2.5 and the NC:C was 3.2 +/- 0.7. Non-compaction was most commonly noted in the apical segments in all patients. LGE was present in 19 of the 47 patients (40%), and most often located in the ventricular septum. The distribution of LGE was subendocardial (n = 5; 6%), mid-myocardial (n = 61; 68%), subepicardial (n = 10; 11%), and transmural (n = 14; 15%) in total of 90 LGE (+) segments.

FindingsAt follow-up, study participants who had received THN tra

FindingsAt follow-up, study participants who had received THN training reported greater overdose-related knowledge relative to those receiving basic information only [OOKS mean difference, 4.08 (95% confidence interval, 2.10-6.06; P<0.001); Cohen's d=0.74 (0.37-1.10)]. There were also more positive opioid overdose-related Bafilomycin A1 manufacturer attitudes among the trained group at follow-up [OOAS mean difference, 7.47 (3.13-11.82); P=0.001; d=0.61 (0.25-0.97)]. At the individual level 35 and 54%, respectively, of the experimental group increased their

knowledge and attitudes compared with 11 and 30% of the control group. During follow-up, 13 participants witnessed an overdose with naloxone administered on eight occasions: five among the THN-trained group and three among the controls.

ConclusionsTake-home naloxone training for family members of heroin users increases opioid overdose-related knowledge and competence and these benefits are well retained after 3 months.”
“Guttate psoriasis, known to have a better prognosis than other types of psoriasis,

shows rapid involution and longer remission, but its clinical course has barely been studied. The aim of this study was to determine the clinical course and to compare the clinical and laboratory features of guttate psoriasis. This is a retrospective study of 26 patients with guttate psoriasis. The patients were divided into two groups; the good one with complete remission and long remission for at least 1 year (group A) and the poor one with incomplete remission VX-680 mw and progression into chronic plaque psoriasis (group CAL-101 supplier B). Among 36 patients, 22 patients (61.1%) were group A and 14 patients (38.9%) were group B. In group A, most of the skin lesions disappeared within 8 months. In group B, two patients without proper treatment progressed to plaque psoriasis. The onset age was younger and more frequent upper respiratory infection and high anti-streptolysin O (ASO) titer were found in group A, but family history of psoriasis was more common

in group B. Patients had two distingushable clinical courses: rapid involuting course with long-term remission and chronic course without remission. There was a tendency toward younger age of onset with elevated ASO titer in patients with rapid involuting course.”
“Background: Pulmonary aspiration is a leading cause of nosocomial infection in the intensive care unit (ICU) and step-down unit (SDU). A key goal is to identify patients who exhibit increased aspiration risk before beginning oral alimentation. This study investigated the success of recommending specific oral diets to ICU and SDU patients based on passing a 3-oz water swallow challenge.

Methods: A referral-based sample of 401 ICU and 92 SDU patients were prospectively analyzed.

The humoral response was analyzed using enzyme-linked immunosorbe

The humoral response was analyzed using enzyme-linked immunosorbent assay (for levels of IgG1, IgG2) and a serum neutralization test (SNT), and the cellular response

using an MTT assay. Significantly higher humoral and cell-mediated immune responses were seen in the P12A3C and the IL-18 coinoculated group than that in P12A3C-pcDNA alone and inactivated virus vaccine inoculated groups. Similarly, a higher population of C188-9 price CD4+, CD8+ and T-helper type 1 (Th1), and Th2 cytokine levels were seen in the former group in comparison with the other groups. P12A3C+IL-18 protected all the six animals when challenged with a homologous virus compared with five and four in an inactivated virus vaccine and the P12A3C-pcDNA groups, respectively. These results have shown that the plasmid encoding for P12A3C-pcDNA, when coinoculated with IL-18, induced

higher responses and protected the animals from a virus challenge.”
“Background: Risk factors and outcome in patients who acquire nosocomial infections due to carbapenem-resistant Acinetobacter baumannii (CRAB) are rarely investigated.

Methods: A multicenter retrospective study was conducted to analyze the clinical and microbiological data of patients with nosocomial infections due to A. baumannii in 10 hospitals around selleck chemical Taiwan from May 2004 to December 2006. Comparisons were made between patients with infections due to CRAB and patients with infections due to carbapenem-susceptible A. baumannii (CSAB).

Results: One hundred and twenty-one patients carrying CRAB (infections, n = 91) and 127 patients carrying CSAB (infections, n = 97) were recruited for analysis. Compared with patients with CSAB infections,

patients with CRAB infections had a longer duration of hospital Autophagy Compound Library stay before A. baumannii was isolated (median 48 vs. 21 days, p < 0.001) and were more likely to have had exposure to a carbapenem (adjusted odds ratio (AOR) 2.57, 95% confidence interval (95% CI) 1.43-5.35; p = 0.02) and an intensive care unit (ICU) stay (AOR 3.42, 95% CI 1.76-5.26; p = 0.008). Risk factors associated with CRAB bacteremia included duration of hospital stay before onset of bacteremia (AOR 1.009 per 1-day longer, 95% CI 1.03-1.24; p = 0.049), prior colonization with A. baumannii (AOR 3.27, 95% CI 1.99-5.93; p = 0.002), and hospitalization in the ICU (AOR 6.12, 95% CI 1.58-13.68; p = 0.009). Patients with CRAB bacteremia had a higher mortality rate than patients with CSAB bacteremia (46.0% vs. 28.3%, p = 0.04). Multivariate analysis showed that carbapenem resistance (AOR 5.31, 95% CI 1.88-13.25; p = 0.002), central venous catheterization (AOR 3.27, 95% CI 1.55-10.56; p = 0.009), and ICU stay (AOR 2.56, 95% CI 1.15-8.85; p = 0.04) were independent variables associated with mortality in patients with A. baumannii bacteremia.

Conclusions: Patients with CRAB infections have a higher mortality rate than those with CSAB infections.

Notably, at y = 7 8, only the D0(3) phase (the equilibrium phase

Notably, at y = 7.8, only the D0(3) phase (the equilibrium phase of Fe-Ge at e/a = 1.54) was found in the ternary alloy. The theory also shows that the D0(3) instability is removed for compositions with y >= 3.9, when D0(3) becomes MLN4924 mouse the structure’s ground-state phase. Thus, the high, positive lambda(gamma,2) value for Fe-Ga at x = 28 could be the result of the high sensitivity of its metastable D0(3) structure. VC 2011 American Institute of Physics. [doi:10.1063/1.3535444]“
“Introduction: We investigated whether

primary prevention implantable cardioverter defibrillator (ICD) patients with atrial arrhythmias are at higher risk for ICD shocks and mortality compared to patients without atrial arrhythmias in a subanalysis TGF-beta inhibitor clinical trial of the PREPARE study.

Methods and Results: Details of the PREPARE study design and results have been previously reported. We now included 537 of the 700 patients enrolled in PREPARE. These patients had a dual or biventricular device and at least one device follow-up after implantation. Continuously collected device diagnostics data were used to classify

patients into two groups during follow-up: with (n = 133) or without (n = 404) atrial tachycardia/atrial fibrillation (AT/AF). The primary outcomes were ICD shocks and mortality. Subjects were followed for a mean of 333 +/- 73 (range 5-365) days. During a follow-up of 1 year, ICD shocks occurred in 44 (8%) patients. Significantly, more patients with AT/AF received a shock (13.0% vs 6.9%, P = 0.03), with inappropriate shocks selleck screening library accounting for the majority of the difference (6.9% vs 2.6%, P = 0.02). There was no difference in prevalence of shocks between patients with and without a history of AF. Mortality was similar in patients with and without AT/AF, whether detected during the study or prior to the study. In addition, the 34 subjects with high average ventricular rate (>= 110 beats per minute) during AT/AF had a higher risk of an inappropriate shock (21.0% vs 2.1%, P < 0.01).

Conclusion: Primary prevention ICD patients with AT/AF are more likely to receive

shocks, especially inappropriate shocks. Mortality was not higher in AT/AF patients. (PACE 2011; 34:1070-1079)”
“Human herpesvirus-6 (HHV-6) belongs to the herpesvirus family and is categorized into variant A and B (HHV-6A and HHV-6B). Primary HHV-6 infection in children and its related diseases are almost exclusively caused by HHV-6B and no disease caused by HHV-6A has been identified. The cellular receptor of HHV-6 has been shown to be a human CD46, and its viral ligand is an envelope glycoprotein complex, gH/gL/gQ1/gQ2 in HHV-6A. Furthermore, both cellular and viral lipid rafts play an important role in the HHV-6 entry process, suggesting that HHV-6 may enter its target cells through a lipid raft-associated mechanism.

We aimed to explore and present the issues and

means thro

We aimed to explore and present the issues and

means through which these women relate their symptoms, treatments and effects. We utilised the ‘cancer journey’ as a heuristic device to chart women’s experiences in the first year following diagnosis.

Method: Thirty-nine interviews were conducted over one year with a convenience sample of 10 women newly diagnosed with breast cancer recruited from a specialist oncology centre in England in 2005. Transcriptions of the interviews were analysed using a thematic narrative approach.

Results: The findings suggested how women related coping and meaning to their experience of relationships, return to work, and self-management of breast cancer symptoms. The overwhelming impact of breast cancer was personal to each sufferer and yet reflects Selonsertib cost commonly reported treatment effects. These included unmet need for fatigue management, the impact of

adaptation to hair loss and disfigurement, and the evident need for sexual health and relationship counselling.

Conclusion: The multi-dimensional aspects of womens’ relationships with family, friends, co-workers and care professionals impacts significantly on their coping strategies and how they GSK3235025 make sense of their breast cancer experiences, which consequently bears upon symptom experience, and experience of survival. We suggest that narrative representation bears witness to the common and differing experiences of how women newly diagnosed with breast cancer cope with symptom experience and survival over time. Narrative representation of breast cancer is a useful pedagogical resource for supportive cancer care and highlights the needs of women that need to be addressed by health care professionals. (C) 2011 Elsevier Ltd. All rights reserved.”
“By using various column selleck kinase inhibitor chromatography for purification, two new compounds of ansamitocin (1 and 2) were isolated from the extracts of fermentation broth of Actinosynnema pretiosum FIM06-0063. Their structures were established as maytansinol-9-methyl ether-3-propionate (1) and maytansinol-9-methyl

ether-3-3-methy-butyrate (2), respectively, by an extensive NMR analysis.”
“We present a detailed study of the magnetic and structural properties of L1(0)-FePt thin films. The films are prepared via molecular beam epitaxy directly onto MgO(001) substrates, i.e., without buffer layer. Despite the large lattice misfit between the in-plane lattice parameters of L1(0) FePt and MgO, highly ordered thin films are obtained with the easy magnetization c axis perpendicular to the film plane. Via high resolution transmission electron microscopy and Rutherford backscattering measurements we focus on the FePt/MgO interface to study the misfit relaxation and the defect density. Further, the influence of elevated substrate temperatures and of postgrowth high temperature annealing on the structural and magnetic properties is discussed. (C) 2009 American Institute of Physics.