The rate of success improved significantly when patients were older than 4 months (88% for patients >

4 months vs 17% for patients <= 4 months, P < .001).

Conclusion: Improved whole-heart MR coronary angiography enables accurate detection of abnormal origin and course of the coronary artery system even in very young patients with congenital heart disease. (C) RSNA, 2011″
“McCune-Albright syndrome (MAS) is characterized by a triad of poly/monoostotic fibrous dysplasia, cafe-au-lait macules and hyperfunctioning endocrinopathies. Association of MAS with GH excess is rare, and in most of the instances somatotropinoma has not been documented. Treatment of patients of MAS with acromegaly is difficult because of thickened calvarium Selleckchem SU5416 and dysplastic skull bone. We report a 17-year-old girl, who presented with cranio-facial fibrous dysplasia, cafe-au-lait macules and also had acromegaly due to Avapritinib clinical trial pituitary macroadenoma, and treated with gamma knife radiosurgery.”
“Pseudomonas aeruginosa is commonly found in chronic lung infections such as cystic fibrosis

and others. Intrinsic antibiotic resistance of P. aeruginosa accompanied by its ability to acquire resistance via mutations and adapt to the heterogeneous and dynamic environment of chronically infected lungs are major threats and reasons for the ultimate failure of the current antibiotic therapies in eradicating the infection from lungs. New insights at molecular levels in the process of accumulating such beneficial mutations at faster rates, termed as hypermutation have allowed us to understand the high acquired resistance of this opportunistic pathogen. Also,

Y-27632 nmr these understandings will allow us to develop new therapeutic strategies to combat chronic infections.”
“Intracardiac lead fracture or free-wall perforation is a rare complication of implantable defibrillators. Complete disconnection of the fractured electrode has not been reported yet. Here, we report a case of lead fracture/disconnection and free-wall perforation, which occurred consecutively in a patient. (PACE 2012; 35:e167e169)”
“Purpose: To compare the image quality and degree of vessel narrowing at flow-sensitive dephasing (FSD) magnetic resonance (MR) angiography of the hands with those at contrast material-enhanced MR angiography of the hands in patients with systemic sclerosis.

Materials and Methods: In a single-center study with institutional review board approval and HIPAA compliance, six healthy volunteers and six patients with systemic sclerosis were imaged at 1.5-T nonenhanced FSD MR angiography followed by contrast-enhanced MR angiography. Sixteen vascular segments in four vessel groups were evaluated for image quality and assessed semiquantitatively for stenosis degree by using Likert scales. The nonparametric Wilcoxon signed rank test was used to perform pairwise comparisons of the MR angiographic techniques. P < .05 indicated statistical significance.

CONCLUSION: The recombinant RD1 antigens induced M. tuberculosis-specific DTH responses. These antigens may therefore be useful in the diagnosis of tuberculosis.”
“BACKGROUND: Data supporting a quinolone or a macrolide as preferred therapy for community-acquired pneumonia (CAP) due to Legionella pneumophila are not firmly established. Some literature suggests a benefit of quinolones learn more over macrolides.

OBJECTIVE: To compare time to clinical stability (TCS) and length of hospital stay (LOS) in patients with Legionella pneumonia who were treated with levofloxacin (LVX) compared to those treated with newer macrolides.

DESIGN: An analysis of patients with Legionnaires’ disease from the Community-Acquired Pneumonia Organization database

was performed. Patients were diagnosed with CAP using radiographic and clinical Ion Channel Ligand Library criteria, while Legionella was detected by urinary antigen or sputum culture. All patients received a macrolide (azithromycin or clarithromycin) or LVX. TCS was defined as the time from hospital admission to candidacy for switch to oral therapy.

RESULTS: A total of 39 patients were included

for analysis. The mean TCS for the macrolidc group was 5.1 days vs. 4.3 days for the LVX group (P = 0.43). The mean LOS for the macrolide group was 12.7 days vs. 8.9 days for the quinolone group (P = 0.10).

CONCLUSION: LOS and TCS were not statistically different between the macrolide and the LVX groups in treating CAP due to Legionella, despite trends in both outcomes favoring LVX.”
“Prurigo pigmentosa is a recurrent dermatosis with severe pruritus and several peculiar clinical features. Its exact etiology and pathogenesis are unclear. The aim of this study was to investigate the clinical features and chronological changes in the histopathology of prurigo pigmentosa in Korean patients and to assess the etiology of this condition. We reviewed the medical records, clinical 5-Fluoracil solubility dmso photographs and biopsy specimens from 50 patients diagnosed with prurigo pigmentosa. Mean age at diagnosis was 23.7 years (range, 15-61 years). Prurigo pigmentosa started as urticarial papules or plaques,

changing first to papulovesicles and then to reticulated brownish macules. The most frequent sites were the back and chest, especially depressed areas such as the central back and inter-mammary area. Dietary change was suspected as a cause of prurigo pigmentosa in 17 patients. Histopathologically, early-stage lesions had dermatitis herpetiformis-like features; fully-developed lesions displayed impetigo-like or acute, generalized, exanthematous, pustulosis-like features; and late lesions presented with post-inflammatory hyperpigmentation-like features. Oral minocycline, with or without dapsone, was effective in inhibiting the appearance of new lesions, but did not prevent recurrence. Prurigo pigmentosa is not rare in Korea, is apparently associated with dietary modification and preferentially involves the depressed regions of the trunk.

Moreover, we studied pro-inflammatory mediators (IL1B and TNF) together with pro-growth signals for investigating their role in chondrocytes

hypertrophy and highlighted the role of underreported players such as Inhibin beta A (INHBA), Defensin beta 1 (DEFB1), CXCL1 and Flagellin, and uncovered the way they cross-react in the phosphoproteomic level.

Conclusions: The analysis presented herein, leveraged high throughput proteomic data via an ILP formulation to gain new insight into chondrocytes signaling and the pathophysiology of degenerative”
“Background: Indications for implantable cardioverter-defibrillators (ICDs) in heart failure (HF) are expanding and may include more than 1 million patients. This study examined patient expectations from ICDs for primary prevention of sudden death in HF.

Methods and Results: Study participants (n = 105) had an EF <35% https://www.selleckchem.com/products/smoothened-agonist-sag-hcl.html and symptomatic HF, without history of ventricular tachycardia/fibrillation or syncope. Subjects completed a written survey about perceived ICD benefits, survival expectations, and circumstances under which they might deactivate defibrillation. Mean age was 58, LVEF 21%, 40% were New York Heart Association Class and 65% already had a primary prevention ICD. U0126 order Most patients anticipated more

than 10 years survival despite symptomatic HF. Nearly 54% expected an ICD to save >= 50 lives per 100 during 5 years. ICD recipients expressed more confidence that the device would save their own lives compared with those without an ICD (P < .001). Despite understanding the ease of deactivation, 70% of ICD recipients indicated they would keep the ICD on even if dying of cancer, 55% even if having daily shocks, and none would inactivate defibrillation

even if suffering constant dyspnea at rest.

Conclusions: HE patients anticipate I-BET-762 research buy long survival, overestimate survival benefits conferred by ICDs, and express reluctance to deactivate their devices even for end-stage disease. (J Cardiac Fail 2010:16:106-113)”
“In order to achieve a reliable degree of quality, the pharmaceutical industry needs to introduce a quality control system that includes validation of the cleaning of equipment. This study carried out cleaning validation on the dexamethasone cream production line. The validation study involved evaluation of the cleaning procedures for the dexamethasone cream production line. Samples were collected at thirteen points involving the reactor, the colloidal mill, the industrial blender, the mixer and the packaging machine, for each of the batches. Samples were collected for study of the residue of the principle active ingredient, of detergent, and for microbiological analysis. Cleaning was shown to be within the stipulated parameters (acceptable level = 9.95 mu g/mL) for: residues of active ingredient, TOC, pH, conductivity and microbiological contamination.

3 +/- 0.6 for micronucleated cells in gill cell of Medaka and 4.6 +/- 0.5 for induction of lymphocyte apoptosis in the thymus of ICR mice.”
“Background: Monoclonal antibodies to Plasmodium lactate dehydrogenase (pLDH) have been previously used to format immunochromatographic tests for the diagnosis of malaria. Using pLDH as an antigen

has several advantages as a sensitive measure of the presence of parasites within this website patient blood samples. However, variable results in terms of specificity and sensitivity among different commercially available diagnostic kits have been reported and it has not been clear from these studies whether the performance of an individual test is due simply to how it is engineered or whether it is due to the biochemical GS-4997 price nature of the pLDH-antibody reaction itself.

Methods: A series of systematic studies to determine how various pLDH monoclonal antibodies work in combination was undertaken. Different combinations of anti-pLDH monoclonal antibodies were used in a rapid test immunochromatographic assay format to determine parameters of sensitivity and specificity with regard to individual Plasmodium species.

Results: Dramatic differences were found in both species specificity and overall sensitivity depending on which antibody is used on the immunochromatographic strip

and which is used on the colorimetric colloidal-gold used for visual detection.

Discussion: The results demonstrate the feasibility of different test formats for the detection and speciation of malarial infections. In addition, the data will enable the development of a universal rapid test algorithm that may potentially provide a cost-effective strategy to diagnose and manage patients in a wide range of clinical settings.

Conclusion: These data emphasize that using different anti-pLDH antibody combinations offers a tractable

way to optimize immunochromatographic pLDH tests.”
“Adrenocortical carcinoma (ACC) is a rare but highly malignant tumor, and its diagnosis is mostly delayed and prognosis is poor. We report estrogen receptor (ER) expression in this tumor Veliparib DNA Damage inhibitor and our clinical experiences with 17 ACC cases.

The data of the 17 patients (9 females and 8 males, age range from 16 to 69 years, mean age of 42.6 years) with ACC were reviewed, and symptoms, diagnostic procedures, treatment, and results of follow-up were evaluated. Immunohistochemistry was used to detect ER expression in tumor samples from the 17 patients.

At the time of diagnosis, 4 tumors were classified as Stage I, 4 as Stage II, 3 as Stage III, and 6 as Stage IV. Eight patients demonstrated positive nuclear immunostaining of ER. The prognosis of patients with ER positive was significantly better (P < 0.05) than that of patients with ER negative, with 1- and 5-year survival rates at 86% and 60% for ER-positive patients, and 38% and 0% for ER-negative patients, respectively.

ER-positivity may be one of the factors associated with a worse prognosis of ACC.

A diamniotic dichorionic term pregnancy was achieved,

ending with the delivery of two healthy girls. As far as is known, this case represents, to date, the longest storage period of cryopreserved human oocytes resulting in a live birth. RBMOnline (c) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“Background: Screening programs to manage osteoporosis in fracture LY3023414 in vivo clinic environments have had varying success in terms of increasing rates of investigation and initiation of treatment for the disease.

Methods: We determined rates of postfracture investigation and care for osteoporosis in patients screened through a coordinator-based initiative in a community hospital fracture clinic. A coordinator screened outpatients, educated them about osteoporosis, advised them to see their family physician for assessment and/or treatment, and performed follow-up at six months. Men who were fifty years of age or older and women who were forty years of age or older

and had a fragility fracture were eligible.

Results: Of 505 patients enrolled at baseline, 332 (66%) returned the follow-up questionnaire; JAK inhibitor 51% of those patients reported having had a bone mineral density test after screening and 26% had initiated first-line treatment (35% if the patients who had already initiated treatment at baseline were excluded) and an additional 23% were continuing treatment since baseline. After adjustment for demographic and baseline variables, patients who had initiated

first-line treatment after screening were 4.15 times more likely to have had a bone mineral density test after screening than patients www.sellecn.cn/products/eft-508.html who had never initiated treatment and 11.67 times more likely to have had a bone mineral density test after screening than patients who had continued treatment since baseline.

Conclusions: A coordinator-based osteoporosis screening program was associated with osteoporosis investigation and treatment. A postfracture bone mineral density test was highly associated with treatment initiation.”
“Traditional dogma suggests that intracytoplasmic sperm injection (ICSI) should be performed to ensure successful oocyte fertilization in an in-vitro maturation (IVM) cycle. This study postulated that there would be no difference in the fertilization rate when ICSI was compared with IVF. This hypothesis was tested in a randomized trial of IVF versus ICSI in IVM. A total of 150 immature oocytes were collected in eight cycles of IVM for patients diagnosed with polycystic ovarian syndrome (PCOS). Patients were primed with minimal FSH before transvaginal oocyte aspiration. Sibling oocytes were inseminated by 50% IVF and 50% ICSI. There was no significant difference in fertilization, useable or total blastocyst development between the two insemination technique groups.

Associations between each form of osteocalcin at baseline and 3-y change in HOMA-IR were examined in 162 adults (mean age: 69 y; 63% female) who did not receive vitamin K supplementation.

Results: Lower circulating uncarboxylated osteocalcin was not associated with higher HOMA-IR at baseline or at 3-y follow-up. Those in the lowest tertiles of total osteocalcin and carboxylated osteocalcin at baseline had higher baseline HOMA-IR (P = 0.006 and P = 0.02, respectively). The concentration

of carboxylated osteocalcin at baseline was inversely associated with a 3-y change in HOMA-IR (P = 0.002).

Conclusions: In older adults, circulating uncarboxylated osteocalcin was not associated with insulin resistance. In contrast, elevated carboxylated osteocalcin and total osteocalcin were associated with lower insulin resistance, Z-DEVD-FMK which supports

a potential learn more link between skeletal physiology and insulin resistance in humans. The role of vitamin K status in this association remains unclear and merits further investigation. This trial is registered at clinicaltrials.gov as NCT00183001. Am J Clin Nutr 2009; 90: 1230-5.”
“In this paper, the effect of ion irradiation on nanoscale hardness of ZnO microcones is reported. The hardness of ZnO cones determined by nanoindentation using atomic force microscope initially increases from 4.7 +/- 1.4 to 9.5 +/- 1.6 GPa after irradiation with 1.2 MeV Ar(+8) ions at an ion fluence of 10(15) ions cm(-2) and then decreases with increasing ion fluence. This change in mechanical hardness has been correlated with the residual stress of the sample revealed by Raman peak shift in the E(2)(H) mode. These results show that the generally reported radiation-hard

nature of ZnO depends critically on irradiation AZD1480 clinical trial conditions, especially the irradiation temperature. (c) 2010 American Institute of Physics. [doi:10.1063/1.3482026]“
“Background: ABO-incompatible living unrelated donor kidney transplantation is an immunologically high-risk procedure, but few reports have been made on the outcomes of these transplants. Patients and Methods: We analyzed 12 kidney transplants using ABO-incompatible living-unrelated donors performed at our institution between January 1999 and December 2007, focusing on the immunosuppressive protocols, complications and graft survivals. Results: Patient and graft survival rates were 100%. One patient experienced antibody-mediated rejection and intractable acute cellular rejection, one had antibody-mediated rejection and one had acute cellular rejection, but their grafts survived after intensive immunosuppressive treatment. There were no severe complications among the recipients.

Copyright (C) 2012 S. Karger AG, Basel”
“This paper introduces the concept of phase-locking analysis of oscillatory cellular signaling systems to elucidate biochemical circuit architecture. Phase-locking is a physical phenomenon that refers to a response mode in which system output is synchronized to a periodic stimulus; in some instances, the number of responses can be fewer than the number of inputs, indicative of skipped beats. While the Androgen Receptor Antagonist observation of phase-locking alone is largely independent of detailed mechanism, we find that the properties of phase-locking are useful for discriminating

circuit architectures because they reflect not only the activation but also the recovery characteristics of biochemical circuits. Here, this principle is demonstrated for analysis of a G-protein coupled receptor system, the M3 muscarinic receptor-calcium signaling pathway, using microfluidic-mediated periodic chemical stimulation of the M3 receptor with carbachol and real-time imaging of resulting calcium transients. Using this approach we uncovered the potential importance of basal IP3 production, a finding that OSI 906 has important implications on calcium response fidelity to periodic stimulation. Based upon our analysis, we also

negated the notion that the Gq-PLC interaction is switch-like, which has a strong influence upon how extracellular signals are filtered and interpreted downstream. Phase-locking analysis is a new and useful tool for model revision and mechanism elucidation; the method complements conventional genetic and chemical tools for analysis selleckchem of cellular signaling circuitry and should be broadly applicable to other oscillatory pathways.”
“An outstanding question regarding magnetic systems is which type of interaction, i.e., ferromagnetic or antiferromagnetic, dominates the interfacial exchange coupling. Here we report magnetic properties of a ferromagnet (FM)-spin glasses (SG) system above the freezing

temperature T(F) = 10.3 K of SG. Our experimental results demonstrate that the effective interfacial exchange coupling in FM-SG system could be either parallel or antiparallel depending on the cooling magnetic field. The compensation cooling magnetic field, which leads to zero effective interfacial exchange coupling and in which the effective interfacial exchange coupling changes sign, is determined. This work opens up many avenues toward the study of SG and the interfacial exchange coupling. (c) 2011 American Institute of Physics. [doi:10.1063/1.3597786]“
“Introduction: This study aims to investigate whether mesothelial cells could function as seed cells to construct tissue-engineered peritoneum-like tissue for urethral reconstruction in a rabbit model. Materials and Methods: Bladder acellular matrices were prepared and trimmed to 1.5 x 1 cm. Nine male rabbits underwent omentum biopsy and autologous mesothelial cells were isolated.

A structure analysis by means of finite element method shows that complete unidirectionality can be reached. First

experimental results are given. (C) 2011 American Institute of Physics. [doi:10.1063/1.3651617]“
“Background: Both orosensory stimulation and feedback from the gastrointestinal tract contribute to energy intake regulation.

Objective: We evaluated the hypothesis that overweight or obese subjects would be less sensitive to both oral and intraduodenal oleic acid exposure than would lean subjects.

Design: Eleven overweight or obese and 8 lean men were studied on 2 occasions, during which antropyloroduodenal pressures, plasma cholecystokinin and peptide YY, and appetite were measured during 90-min intraduodenal infusions of saline or oleic acid (18: 1 load: 0.78 kcal/min);

INCB028050 energy intake (buffet lunch) was determined immediately afterward. Oral detection thresholds for 18: 1 and recent dietary intake (2-d recall) were also quantified.

Results: this website In lean subjects, the number of isolated pyloric pressure waves (IPPWs) was greater during 18: 1 infusion than during saline infusion (P < 0.05); no significant differences were observed between the 18: 1 and saline infusions in the overweight or obese subjects. In both groups, 18: 1 stimulated plasma cholecystokinin and peptide YY and suppressed energy intake compared with saline (P < 0.05), with trends for reduced cholecystokinin and energy intake responses in the overweight or obese subjects. Detection thresholds for 18: 1 were greater in overweight or obese (7.9 +/- 0.1 mmol/L) than in lean (4.1 +/- 0.4 mmol/L) subjects (P < 0.05). Overweight or obese subjects had greater recent energy (P < 0.05) and fat (P = 0.07) intakes than did lean subjects. There was a direct relation (r = 0.669) of body mass index with 18: 1 detection thresholds and inverse relations (r < -0.51) of IPPWs with body mass index and 18: 1 detection thresholds (P < 0.05).

Conclusions: The ability to detect

oleic acid both orally and within BEZ235 mw the gastrointestinal tract is compromised in obese men, and oral and gastrointestinal responses to oleic acid are related. This trial was registered at www.actr.org.au (Australian New Zealand Clinical Trials Registry) as 12609000557235. Am J Clin Nutr 2011;93:703-11.”
“Antibody-mediated hyperacute rejection was the first rejection phenotype observed in human organ transplants. This devastating phenotype was eliminated by reliable crossmatch technologies. Since then, the focus was on T-cell-mediated rejection and de novo donor-specific antibodies were considered an epiphenomenon of cognate T-cell activation. The immune theory was that controlling the T-cell response would entail elimination of antibody-mediated rejection (ABMR). With modern immunosuppressive drugs, T-cell-mediated rejection is essentially treatable.

The highest catalytic activity was exhibited in a 0.05 M phthalate buffer (pH 5.9-6.2) by the complex containing 0.006-0.009% chitosan in the indicator reaction. The activatory

effect of the polysaccharide on the enzyme was determined by its influence on the binding and conversion of the reducting substrate peroxidase.”
“Introduction: Early prediction of drug-induced functional cardiotoxicity requires robust in-vitro systems suitable for medium/high throughput and easily accessible cardiomyocytes with defined reproducible Volasertib concentration properties. The xCELLigence Cardio system uses 96-well plates with interdigitated electrodes that detect the impedance changes of rhythmic contractions of stem cell-derived cardiomyocyte (SC-CM) layers. Here, we report on our initial screening experience in comparison to established (multi) cellular and in-vivo models. Methods: Impedance signals from human iPSC-CM (iCells (TM)) and mouse eSC-CM (Cor.At (TM)) were analyzed for Apoptosis Compound Library supplier contraction amplitude (CA) and duration, rise/fall time, beating rate (BR) and irregularity.

Results: Following solution exchange, impedance signals re-approximated steady-state conditions after about 2 (Cor.At (TM)) and 3 h (iCells (TM)); these time points were used to analyze drug effects. The solvent DMSO (<= 1%) hardly influenced contraction parameters in Cor.At (TM), whereas in iCells (TM) DMSO (>0.1%) reduced CA and enhanced BR. The selective hERG K+ channel blockers E-4031 and dofetilide reduced CA and accelerated BR (>= 30 nM) according to ACP-196 purchase the analysis software. The latter, however, was due to burst-like contractions (300 nM) that could

be detected only by visual inspection of recordings, and were more pronounced in Cor.At (TM) as in iCells (TM). In cardiac myocytes and tissue preparations, however, E4031 and dofetilide have been reported to increase cell shortening and contractile force and to reduce BR. Compounds (pentamidine, HMR1556, ATX2, TTX, and verapamil) with other mechanisms of action were also investigated; their effects differed partially between cell lines (e. g. TTX) and compared to established (multi) cellular models (e. g. HMR1556, ouabain). Conclusion: Mouse and human stem cell-derived cardiomyocytes respond differently to drugs and these responses occasionally also differ from those originating from established in-vitro and in-vivo models. Hence, drug-induced cardiotoxic effects may be detected with this system, however, the predictive or even translational value of results is considered limited and not yet firmly established. (C) 2013 Elsevier Inc. All rights reserved.”
“Introduction: Systemic capillary lactate, an end product of cellular anaerobic metabolism, has not established credibility in monitoring limb reperfusion.

1%) had severe pre-eclampsia. Mean serum hs-CRP of the pre-eclamptic group was higher than that of the normotensive group (7.062.6mg/L vs 3.62.3mg/L, P=0.001). The receiver-operator curve showed a significant difference between the under-curve zone for the hs-CRP level with the reference line. Serum hs-CRP of 4mg/L showed sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy as 78.1%, 72.1%, 25%, selleck chemicals llc 96.5% and 72.8%, respectively. Hs-CRP of more than 7mg/L was found in 26 (61.9%) cases of pre-eclampsia and 22 (6.25%) normotensive pregnancies, which

showed a significant difference (P=0.001, relative risk=12.1, 95% confidence interval: 6.91-21.15). Hs-CRP of more than 7mg/L was found in 17 (73.91%) cases of severe pre-eclampsia and 22 (6.25%) normotensive pregnancies, which showed a significant difference (P=0.001, relative risk=9.35, 95% confidence interval: 4.48-19.52).

ConclusionHs-CRP measurements during the first trimester of pregnancy are helpful in predicting pre-eclampsia.”
“Background: It is unclear whether measures of glycemic status beyond fasting glucose (FG) levels improve incident heart failure (HF) prediction in patients without history www.selleckchem.com/products/ly2157299.html of diabetes mellitus (DM).

Methods and Results: The association of measures of glycemic Status at baseline (including FG, oral glucose tolerance testing [OGTT], fasting

insulin, hemoglobin A(1c) [HbA(1c)] levels, and homeostasis model assessment of insulin resistance [HOMA-IR] and insulin secretion [HOMA-B]) with incident HF, defined as hospitalization for new-onset HF, was evaluated in 2386 elderly participants without history of DM enrolled in the Health, Aging, and Body Composition Study (median age, 73 years; 47.6% men; 62.5% white, 37.5% black) using Cox models. After a median follow-up of 7.2 years, 185 (7.8%) participants developed HE Incident HF rate was 10.7 cases per 1000 person-years with FG < 100 mg/dL, 13.1 with FG 100-125

mg/dL, and 26.6 with FG >= Selleck Tideglusib 126 mg/dL (P = .002; P = .003 for trend). In adjusted models (for body mass index, age, history of coronary artery disease and smoking, left ventricular hypertrophy, systolic blood pressure and heart rate [HR], and creatinine and albumin levels), FG was the strongest predictor of incident HF (adjusted HR per 10 mg/dL, 1.10; 95% CI, 1.02-1.18; P = .009); the addition of OGTT, fasting insulin, HbA(1c), HOMA-IR, or HOMA-B did not improve HF prediction. Results were similar across race and gender. When only HF with left ventricular ejection fraction (LVEF) <= 40% was considered (n = 69), FG showed a strong association in adjusted models (HR per 10 mg/dL, 1.15; 95% CI, 1.03-1.29; P = .01). In comparison, when only HF with LVEF > 40%, was Considered (n = 71), the association was weaker (HR per 10 mg/dL, 1.05; 95% CI; 0.94-1.18; P = .41).

Conclusions: Fasting glucose is a strong predictor of HF risk in elderly without history of DM.