The filter that narrows the focus saves considerable time and resources during updates of this online resource, without sacrificing sensitivity.”
“BACKGROUND: Although treatment of latent tuberculosis infection (LTBI) is an essential component of tuberculosis (TB) control in countries such as the United States, it is not widely practiced in most TB-endemic countries.

OBJECTIVE: To examine the practice of and adherence to LTBI treatment in a high-risk population in Brazil.

DESIGN: We followed household contacts

(HHCs) of patients hospitalized with pulmonary TB in Salvador, Brazil, for 6 months after they initiated LTBI treatment with isoniazid (INH). HHCs were asked to return to the hospital once a month for 6 months for follow-up visits and INH refills.

RESULTS: Of 101 HHCs who initiated LTBI treatment, selleck chemicals 54 (53.5%) completed the 6-month regimen. The risk of treatment non-completion was significantly higher in HHCs who reported side effects to INH (RR 2.69, 95%CI 1.3-5.8, P = 0.01), and in those who had to take two buses for a one-way trip to the hospital (RR 1.8, 95%CI 1.01-3.3, P = 0.04). Of the 101 HHCs, 29 (28.7%) did not return for any follow-up visits; these HHCs were significantly more SN-38 manufacturer likely to have a 2-bus commute to the hospital compared to HHCs who completed treatment (OR 20.69, 95%CI

2.1-208.4, P = 0.01).

CONCLUSION: Nearly 50% of HHCs at high risk for developing TB completed a 6-month course Alvespimycin order of LTBI treatment. Completion of LTBI treatment was most affected by medication intolerance and commuting difficulties for follow-up visits.”
“BACKGROUND: Cardiovascular diseases are a major cause of morbidity and mortality in India,

with dyslipidemia contributing significantly to the risk. There are few community-based studies that highlight the burden and risk factors associated with dyslipidemia in the Indian population.

OBJECTIVES: To determine the prevalence and risk factors associated with dyslipidemia among adults ages 18 years and older in a resettlement colony located in central Delhi.

METHODS: A cross-sectional study that included a random sample of 200 adults was designed. A study tool based on the World Health Organization STEPwise approach to surveillance of noncommunicable diseases and their risk factors (STEPS) questionnaire was used. Fasting venous blood sample was collected to assess the lipid profile and anthropometric measures of the participants were recorded. Criteria based on the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults were used to define the cut offs for dyslipidemia. Data were analyzed with the Statistical Package for Social Sciences, version 17.

(C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012″
“Purpose: To determine the effects of combined treatment with corticotomy and skeletal anchorage in open bite correction.

Patients and Methods: Ten patients (6 females, 4 males) with ages click here ranging from 15 to 25 years were involved. All of the individuals received combined subapical corticotomy and skeletal anchorage procedure and intrusion forces of 200 to 300 g were applied on the attachments of

each molar and both premolars during 12 to 15 weeks. Mean changes for the measurements for the sample group were evaluated with Wilcoxon signed ranks test.

Results: Significant intrusion of maxillary posterior teeth provided counterclockwise rotation of the mandible and open bite was successfully corrected. SNB angle increased and the ANB angle decreased (P < .05). Significant decreases were noted for vertical skeletal characteristics and overbite increased accordingly (P < .05).

Conclusions: our results

indicated that the use of combined treatment with corticotomy and skeletal anchorage provided safe and noncompliance intrusion of posterior teeth in a short period and may be regarded as an alternative method for skeletal open bite correction in adults who reject orthognathic surgery. (C) CYT387 2009 American Association of Oral and Maxillofacial Surgeons”
“We study photo-induced static and dynamic spectral changes in self-assembled CdSe/ZnS quantum dot (QD) thin films with varying QD concentrations under ambient conditions. Using spatially resolved scanning photoluminescence microscopy in conjunction with spectrally resolved

time-correlated photon counting, we measure the variations in spectral intensity, emission wavelength, and recombination lifetimes as functions of photo-exposure time. We find that at low concentrations MI-503 supplier photo-darkening and photo-oxidation rates slow down with increasing QD density, but in the high concentration limit these rates are strongly enhanced. Our measurements lead us to conclude that the interplay of photo-induced surface trap discharging with preferential photo-oxidation of smaller QDs is further modulated by resonant energy transfer driven by strong inter-dot interactions in highly concentrated samples. Our results would imply that the efficiency and longevity of semiconducting nanoparticle based opto-electronic devices will be limited by the concentration of the active material (C) 2011 American Institute of Physics. [doi: 10.1063/1.3630977]“
“The plant hormone jasmonate (JA) plays important roles in the regulation of plant defence and development. JASMONATE ZIM-DOMAIN (JAZ) proteins inhibit transcription factors that regulate early JA-responsive genes, and JA-induced degradation of JAZ proteins thus allows expression of these response genes.

9%), www.selleckchem.com/products/BEZ235.html and 1 nonunion (2.9%). The matrix strut miniplate offers surgeons another tool to successfully accomplish mandibular fixation expediently while minimizing additional risk to patients. This system adds superior stability

without negatively impacting other aspects of care and should be strongly considered for angle fixation.”
“Prostate cancer is the most prevalent form of cancer in western men. An accurate early localization of prostate cancer, permitting efficient use of modern focal therapies, is currently hampered by a lack of imaging methods. Several methods have aimed at detecting microvascular changes associated with prostate cancer with limited success by quantitative imaging of blood perfusion. Differently, we propose contrast-ultrasound diffusion imaging, based on the hypothesis that the complexity of microvascular changes is better reflected by diffusion than by perfusion characteristics. Quantification of local, intravascular diffusion is performed

after Selleck Geneticin transrectal ultrasound imaging of an intravenously injected ultrasound contrast agent bolus. Indicator dilution curves are measured with the ultrasound scanner resolution and fitted by a modified local density random walk model, which, being a solution of the convective diffusion equation, enables the estimation of a local, diffusion-related parameter. Diffusion parametric images obtained from five datasets of four patients were compared with histology data on a pixel basis. The resulting receiver operating characteristic (curve area = 0.91) was superior to that of any perfusion-related parameter proposed in the literature. Contrast-ultrasound diffusion imaging seems therefore to be a promising method for prostate cancer localization, encouraging further research to assess the clinical reliability.”
“Background: Current cardiovascular magnetic resonance (CMR) methods, such as late gadolinium enhancement (LGE) and oedema imaging (T2W) used to depict myocardial ischemia, Blebbistatin datasheet have limitations. Novel quantitative T1-mapping techniques have the potential to further characterize the components of ischemic injury. In patients with myocardial

infarction (MI) we sought to investigate whether state-of the art pre-contrast T1-mapping (1) detects acute myocardial injury, (2) allows for quantification of the severity of damage when compared to standard techniques such as LGE and T2W, and (3) has the ability to predict long term functional recovery.

Methods: 3T CMR including T2W, T1-mapping and LGE was performed in 41 patients [of these, 78% were ST elevation MI (STEMI)] with acute MI at 12-48 hour after chest pain onset and at 6 months (6M). Patients with STEMI underwent primary PCI prior to CMR. Assessment of acute regional wall motion abnormalities, acute segmental damaged fraction by T2W and LGE and mean segmental T1 values was performed on matching short axis slices.

In addition, although mild cognitive impairment (MCI) is recognized as a risk factor for dementia, it remains a challenge to predict on an individual level who will convert to become demented.

Amyloid beta (A beta) is one of the crucial pathological findings in AD. Recently, amyloid tracers for PET imaging have been developed successfully which may offer the unique possibility

for measuring fibrillar A beta load in the living brain. Therefore, in the near future positron emission tomography (PET) may become an important tool for in vivo amyloid imaging contributing to early (differential) diagnosis as well as evaluation of treatment response in AD. Moreover, A beta may play a role in prediction the conversion of MCI to AD. In this paper we review the recent development of the molecular Selleckchem Bioactive Compound Library imaging technique PET and its different radiopharmaceuticals on the trail for imaging amyloid in AD and the conversion of MCI to AD.”
“Phosphatidylcholine (PC) and its hydrolysates are considered to stimulate intestinal

lipid absorption, however, their exact effects on lipoproteins and apolipoprotein (apo) metabolism remain ambiguous. This study aimed to further differentiate the effects of them using fully differentiated enterocyte-like Caco-2 cells. Lipid micelles (oleic acid 0.6, cholesterol 0.05, monooleylglycerol 0.2, taurocholate 2 in mmol/l) with or without choline, PC, and lysoPC (0.2 mmol/l each) were applied apically to Caco-2 cells. H-3-oleic acid and C-14-cholesterol Epigenetics inhibitor were added to the micelles when necessary. Secreted lipoproteins were analyzed Selleck GM6001 by a HPLC method. LysoPC had the most potent promoting effect on

lipid uptake, and lipoprotein and apolipoprotein B-48 secretion among the molecules tested. LysoPC doubled the output of cholesterol and triglyceride as the lipoprotein component, but PC did not. On the other hand, PC only increased the secretion of apoA-IV in the presence of lipid micelles. These findings confirm that the alteration of PC by PLA(2) hydrolysis is intrinsically involved in the intestinal lipid absorption process and suggest that PC and its hydrolysis are coordinately associated with not only lipid absorption efficiency but also lipoprotein output and metabolism.”
“Objective-To assess clinical outcomes and scintigraphic findings in horses with a bone fragility disorder (BFD) treated with zoledronate (a nitrogen-containing bisphosphonate).

Design-Prospective uncontrolled clinical trial.

Animals-10 horses with evidence of a BFD.

Procedures-Signalment, history, and geographic location of horses’ home environments were recorded. Physical examinations, lameness evaluations, and nuclear scintigraphy were performed. Diagnosis of a BFD was made on the basis of results of clinical and scintigraphic examination. Each horse was treated with zoledronate (0.075 mg/kg [0.034 mg/lb, IV, once]) at the time of diagnosis.

The enzyme Pectinex (R) SP ULTRA gave the best performance, with the shortest incubation time. The best results were observed after 30 min of incubation; more than 70% of the metaphases did not have large amounts of cytoplasm or overlapping chromosomes, and about 75% maintained the chromosome number. FISH was carried out using a 45S rDNA probe (pTa71) labeled with biotin and detected with fluorescein isothiocyanate. Sites with strong staining and without nonspecific signals were observed. Our methodological adaptations

allowed the preparation of metaphase slides of high quality for the FISH technique, with less time required for the preparation of samples.”
“Background: An increase in gastrointestinal viscosity or colonic fermentation is suggested to improve appetite control and reduce food intake. It has been proposed that beta-glucan GSK J4 order and fructooligosaccharide (FOS) are food ingredients that increase gastrointestinal viscosity and colonic fermentation, but the results are inconclusive.

Objective: The objective was to test the selleck chemicals llc effect of FOS, beta-glucan, or a combination thereof on appetite ratings and food intake over 2 consecutive days.

Design: In a 4-way balanced-order, crossover, double-blind design, 21 healthy volunteers [mean body mass index (in kg/m(2))

25.9] consumed a meal-replacement bar at 0900 and an ad libitum lunch at 1300 on 2 consecutive days. On day 1 only, the subjects consumed a second

(identical) bar at 1700 and a fixed snack at 1900. The control bar contained 0.3 g beta-glucan from 6.8 g oats (control), and the 3 equicaloric test bars contained an additional 0.9 g beta-glucan (from 8.0 g barley), 8 g FOS, or 0.9 g beta-glucan + 8 g FOS. Appetite scores and subsequent ad libitum test meal intakes were measured. Viscosities in response to bar consumption were determined under simulated gastric EGFR inhibitor conditions. The results were analyzed by analysis of covariance.

Results: The addition of beta-glucan, FOS, or a combination thereof did not affect appetite ratings or food intake, although the addition of beta-glucan to the bar doubled gastric viscosity (841 compared with 351 mPa.s).

Conclusions: Consumption of beta-glucan, FOS, or a combination thereof in meal-replacement bars at the levels tested for 2 consecutive days does not improve appetite control. Efficacy may have improved if the consumption period was longer, if the content of beta-glucan was greater, or if a form of beta-glucan that generates even higher gastric viscosity was consumed. This trial was registered at clinicaltrials. gov as NCT00776256. Am J Clin Nutr 2009; 89: 58-63.”
“Background Many devices used in dermatology lack generic names. If investigators use commercial device names, they risk the appearance of bias. Alternatively, reliance on ad-hoc names and abbreviations may confuse readers who do not recognize these.

All patients who had previous Fontan surgery and who subsequently underwent liver biopsy at our institution between January 1990 and July 2010 were identified. For each biopsy specimen, portal and sinusoidal fibrosis were graded and medical records reviewed. Biopsy specimens from 13 patients were examined; the median time from

Fontan surgery to liver biopsy procedure was 16.9 years (range 6.9-25). At the most recent biopsy procedure, 12 patients (92 %) had evidence of portal fibrosis, including 1 patient with portal-based cirrhosis. Thirteen patients (100 %) had at least some degree of sinusoidal fibrosis, including 1 patient with centrilobular-based cirrhosis. Lower platelet count was associated AG-014699 mouse with greater degree of portal fibrosis by ordinal regression (odds ratio 0.84, P = 0.04), and patients with no or mild portal fibrosis had significantly higher platelet counts compared with those with moderate or severe portal disease

(278 +/- A 78 K vs. 160 +/- A 46 K, P = 0.005). Four patients underwent serial biopsy procedures; portal fibrosis was progressed in 3 patients, and sinusoidal fibrosis was progressed in 3 patients. After Fontan surgery, portal and sinusoidal fibrosis are common at liver biopsy and can progress over time. Lower platelet count may represent a marker of portal-based disease in these patients.”
“The delivery rates of 298 patients having selleck chemical preimplantation genetic diagnosis with aneuploidy screening (PGS) were compared with the delivery

rates of 144 PGS patients that cancelled the plan for PGS with embryo transfer on day 2 or day 3. The goal of this study was to compare the impact of embryo de-selection with PGS to embryo selection using sequential embryo scoring (SES) on outcome in poor-prognosis patients. Embryos with good sequential scores were more likely to have a normal PGS result than embryos with poor SES scores find more (34% versus 12%; P < 0.05). Patients proceeding with PGS had an overall delivery rate of 15% per oocyte retrieval. There was a significant difference in delivery rates between patients with less than six embryos and patients with greater than six embryos (6% versus 19%; P < 0.005). The overall delivery rate for patients having transfers without PGS was 23% (P < 0.05 compared with PGS patients) with no difference between low and good responders. It was concluded that PGS neither enhanced nor impaired delivery rates in high responding poor-prognosis patients yet SES may be more accurate than PGS as a means of selection for low-responding poor-prognosis patients. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“The National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC) registry captures information on interstage management of infants with hypoplastic left heart syndrome (HLHS).

A series of N-substituted cis-tetra- and cis-hexahydrophthalazinone derivatives

have been reported as novel, selective PDE-4 inhibitors with potent anti-inflammatory activity. In order to gain further insights into the structural requirements of novel series of N-substituted cis-tetra and cis-hexahydrophthalazinone derivatives as PDE-4 inhibitors, a three-dimensional quantitative structure activity Microtubule Associat inhibitor relationship (3D-QSAR) was performed using Genetic Function Approximation (GFA). The QSAR model was generated using a training set of 45 molecules and the predictive ability of the resulting each model was assessed using a test set of 9 molecules. The internal and external consistency of final QSAR model was 0.675 and 0.750 respectively. Analysis of results from the present QSAR study indicates that shape and structural descriptors strongly govern the PDE-4 enzyme inhibitory activity. This QSAR study highlights the structural features required for PDE-4 enzyme inhibition and may be useful for design of potent PDE-4 inhibitors.”
“We demonstrate the possibility of doubling the areal density of information in magnetic patterned media by stacking decoupled in-plane and perpendicular-to-plane magnetized layers. Each dot can be set in four magnetostatically equivalent configurations, yielding a storage capability of two-bits per dot. Magnetic force microscopy analyses show that the magnetic signal from the out-of-plane

magnetized layer is dominant right above the dots, whereas, the signal from the in-plane magnetized layers is largest above the spacing Iressa between dots. This results in an optimal use of the storage AZD7762 research buy space and in an increase of the areal density with weak loss in readout signal-to-noise ratio. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3572259]“
“Objective: Maximum seizure

control, preservation of cognition, and prevention of developmental hindrance are major aims of the pharmacological treatment of children and adolescents with epilepsy. Herewith we introduce the junior version of EpiTrack, a 12- to 15-minute screening test for monitoring the cognitive effects of antiepileptic drug treatment in children and adolescents aged 6 to 18.

Methods: The test, which comprises six subtests (Speed, Flexibility, Planning, Response Inhibition, Word Fluency, Working Memory), was administered to 277 children and adolescents aged 6-18 years, 111 of whom were retested after an interval of 3 months. For the first clinical validation, 155 patients (46% idiopathic/benign, 62% seizure free) were evaluated.

Results: Standardization and correction for age resulted in a mean score of 33 +/- 2 points, which was no longer correlated with age (r = 0.005). The retest practice effect was 0.7 +/- 2 points, and the reliability r(tt) = 0.78. Factor analysis indicated one executive factor in controls and patients. In the epilepsy group, 50% of the patients were impaired (controls 14%).

M. immunogenum is resistant to many anti-mycobacterial agents, and treatment can be especially challenging in transplant patients, given potential Dactolisib in vitro drug interactions and added toxicities. It is important to distinguish M. immunogenum from other RGM and determine the susceptibility

profile to devise a successful treatment plan, particularly in the transplant population in which it can potentially cause severe, disseminated disease.”
“To compare “”for cause” renal biopsies (bx) from adult recipients of pediatric-donor kidneys (PDK) versus adult-donor kidneys (ADKs), we reviewed 103 graft bx from 50 PDK recipients and 85 bx from 49 ADK recipients. PDK bx displayed more frequent glomerular pathology with immune complex-mediated glomerulonephritis present in 11/103 PDK versus 1/85 ADK (p < 0.05). In 15/103 PDK bx and 1/85 ADK (p = 0.001), the association of glomerular sclerosis, expanded mesangium, and halo of prominent podocytes by light microscopy, and ultrastructural glomerular basement membrane lamellation, configured a characteristic glomerulopathy.”
“Objective.

The primary aim of the present study was to investigate whether there is a relationship between central hypersensitivity (assessed by pressure pain thresholds of uninjured tissues) and intradiscal pain threshold during

discography. S63845 inhibitor The secondary aim was to test the hypothesis that peripheral noxious stimulation dynamically modulates central hypersensitivity.

Patients.

Twenty-four patients with positive provocation discography were tested for central hypersensitivity by pressure algometry before and after the intervention with assessments of pressure pain detection and tolerance thresholds. Intradiscal pain threshold was assessed by measuring intradiscal pressure at the CP-456773 concentration moment of pain provocation during discography. Correlation

analyses between intradiscal pain threshold and pressure algometry were made. For the secondary aim, pressure algometry data before and after discography were compared.

Results.

Significant correlation with intradiscal pain threshold was found for pressure pain detection threshold at the toe (regression coefficient: 0.03, P = 0.05) and pressure pain tolerance thresholds at the nonpainful point at the back (0.02, P = 0.024). Tolerance threshold at the toe was a significant predictor for intradiscal pain threshold only in multiple linear regression (0.036, P = 0.027). Detection as well as tolerance thresholds significantly decreased after discography at the painful and the nonpainful point at the back, but not at the toe.

Conclusions.

Central hypersensitivity may influence intradiscal pain threshold, but with a modest quantitative impact. The diagnostic value of provocation discography is therefore not substantially impaired. Regional, but not generalized central hypersensitivity is dynamically modulated by ongoing peripheral nociceptive input.

(C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 114: 1864-1869, 2009″
“The effects of oxidation time and annealing conditions on sputter-deposited magnetic tunnel junctions with a TiOx barrier have been investigated. High resolution electron microscopy showed that longer oxidation times led to a significant increase in barrier layer width and to the formation of large volumes of oxides of Co and Fe. Annealing promoted extensive diffusion of Mn to the barrier region and the oxidation of Mn to MnOx concurrent with the reduction in oxides of Co and Fe. Annealing also increased the peak oxygen content of the barrier region and resulted in a distinct asymmetry

in the barrier oxide structure.”
“Proinflammatory Selleck Pevonedistat components are present in abdominal aortic aneurysm (AAA). Circulating monocytes display heterogeneity, and three subsets have been identified, based on the differential

expression for CD14 and CD16 receptors: CD14(+)CD16(-), GSK1210151A datasheet classical, CD14(+)CD16(+), intermediate and CD14(dim)CD16(+), non-classical monocytes. Increased proinflammatory CD16(+) monocytes with high expression of CD143 are present in CKD patients. D-dimer is increased in AAA patients, and might contribute to the pro-inflammatory response associated to circulating monocytes. We aimed to investigate the frequency of CD14(+)CD16(+), CD14(dim)CD16(+) monocytes and monocyte CD143 expression in AAA patients, and their relationship with D-dimer, eGFR and other inflammatory parameters. Blood from 74 AAA patients

and 30 healthy controls was analyzed to determine the frequency of CD14(+)CD16(+), CD14(dim)CD16(+) monocytes and the monocyte CD143 expression by means of flow-cytometry. AAA patients had expanded CD16(+) subsets (CD14(+)CD16(+): 7.66 +/- 0.31% vs 5.42 +/- 0.27%; CD14(dim)CD16(+): 7.43 +/- 0.48% vs 5.54 +/- 0.38%, AZD8186 in vivo AAA vs controls, mean +/- SE, both p < 0.05). CD14(+)CD16(+) cells were associated to D-dimer and age, and to reduced eGFR. CD14(dim)CD16(+) cells were associated to uric acid, surface CD143, and reduced count of total leukocytes and neutrophils. Within AAA patients, the two CD16(+) subsets and the monocyte CD143 expression display different relationships with D-dimer, parameters of renal function and circulating biochemical and inflammatory biomarkers.”
“Melamine-formaldehyde-polyvinylpyrrolidone (MFP) polymer resin was prepared with 1 : 16 : 1 ratios of melamine, formaldehyde (CH(2)O), and polyvinylpyrrolidone amounts, respectively, by condensation polymerization at 6.9 pH. Structures were determined with IR, (1)H-NMR, and (13)C-NMR spectroscopies. Chemical shifts (delta, ppm) were analyzed with singlet at delta 4.5, duplet from 3.13 to 3.17 and a quartet at 1.5 to 2.2 ppm for methylene (-CH(2)-) bridging group, pyrrolidone and polyvinyl constituents. The 3389.25, 1290.38, and 1655.

We transduced rat hippocampal neurons, which were cultured on glial micro-islands, with lentiviruses expressing wild-type or mutant human KCNA1, and injected

either depolarizing currents to evoke action potentials or depolarizing voltage commands to evoke autaptic currents. alpha-Dendrotoxin and tetraethylammonium allowed a pharmacological dissection of potassium currents underlying excitability and neurotransmission. Overexpression of wild-type Kv1.1 decreased both neuronal excitability and neurotransmitter release. By contrast, the C-terminus-truncated R417stop mutant, which is associated with severe drug-resistant EA1, had the opposite effect: increased excitability and release probability. Another mutant, T226R, which is associated with EA1 that is complicated by contractures AZD9291 and

epilepsy, had no detectable effect on neuronal excitability; however, in common with R417stop, it markedly enhanced neurotransmitter release. The results provide direct evidence that EA1 mutations increase neurotransmitter release, and provide an insight into mechanisms underlying the phenotypic differences that are associated with different mutations.”
“Background: Lymphadenitis is one of the presenting signs of toxoplasmosis. Co-trimoxazole (CTM) has a good therapeutic effect on ocular and cerebral infections caused by Toxoplasma gondii. Since this infection is endemic in Ahvaz and because of the lack of investigations into the therapeutic effects of CTM in toxoplasmic lymphadenitis (TL), this study was performed from 2005 to 2007 to determine the therapeutic effects of CTM on TL in IWR-1-endo Ahvaz.

Methods: Forty-six patients with TL were enrolled in

this randomized, double-blind, check details placebo-controlled trial study. Diagnosis was based on clinical examination, serological tests (chemiluminescent), and histopathological examinations. Palpable lymph nodes, IgM > 8 IU, and follicular hyperplasia were defined as positive findings. Patients were randomly assigned to the comparison groups (23 patients in each group). The CTM patients were treated with 48 mg/kg/day CTM divided into two doses, for 1 month. The placebo patients were treated with placebo for 1 month. The primary endpoint for treatment response was 1 month. Follow-up with physical and serological examinations occurred at 6 months. The secondary endpoint was at 6 months. Clinical response was defined as no palpable lymph nodes and serological response as IgM < 6 IU; a patient was cured if the lymph nodes were no longer palpable and IgM was < 6 IU. Results were analyzed using SPSS software and the Chi-square test.

Results: At the end of treatment, a clinical response was observed in 15 (65.2%) in the CTM group and five (21.7%) in the placebo group. A serological response was seen in 65.2% of the CTM group and 13.0% of the placebo group. The cure rate was 65.2% in the CTM group and 13.1% in the placebo group. There was a significant difference in therapeutic effect between the two groups (52.