To address these issues, a component-based framework has been developed in the GiraffPlus project. In this framework, different components can be deployed to accomplish its relative task. The aggregation, fusion and filtering of data coming from the WSNs are done in specific components called gateways, which, being aware of the particular technology below them, collect and aggregate sensed data and present it in a common format for all the applications in a transparent way. The context recognition component, for example, can use these data without worrying about the particular communication protocol needed to gather them. In the same way, a specific component offers a secure and reliable channel to gather and store data, hiding all the complexity of handshaking and the replica mechanism to the application components in the common APIexposed by the low level layers (connectors) to the upper layers (applications).

In this context, the integration of all components is done by means of a distributed middleware, which is able to hide the heterogeneity of the sensor devices. This kind of architecture, composed of different layers that communicate through a middleware layer, is becoming increasingly important [6]. Since 1997, the OSGiplatform has attracted much attention among the middleware technologies, thanks to the modularity layer it adds on top of the Java programming language and the service-oriented architecture (SOA) adopted to dynamically bind service components. It has been recognized as the Java middleware, and it became mainstream in 2003, when big players, like IBM and Oracle, started to adopt OSGi as the foundation run-time for enterprise applications (i.

e., Eclipse). In the academic world, the SOCAMarchitecture [7] was one of the first to suggest an OSGi-based infrastructure for context-aware applications. In fact, OSGi is suitable for acting as a smart gateway able to link different network technologies, but still providing the easy extendability and configurability of the system, which are valua
Being Dacomitinib considered as one of the important transition elements in biological systems, vanadium is an ultra-trace metal that can be found in some marine organisms, in the prosthetic group of bromoperoxidases in certain marine algae [1�C3], as part of the nitrogenase system of some bacteria and plants [4,5], as well as in plasma and inside cells of mammals [6].

It participates in the synthesis of chlorophyll in photosynthetic organisms and is a micronutrient of marine and terrestrial species [7].In the past, vanadium compounds were used as a therapeutic agent for diabetes, anemia, chlorosis, and even for tuberculosis. It is also a tonic, antiseptic and as a spirocheticide. Nevertheless vanadium, especially as vanadium pentoxide, has a broad spectrum of known toxic effects on the respiratory, circulatory and central nervous systems, digestive organs, kidneys and skin in humans.