7, 8.1 and 9.8 mu g mL(-1), respectively. Moreover, the extracts of S. cordifolia, U. lancaefolia and A. chiangdaoense have shown slightly synergistic effects (combination index; CI < 1)
with L-ascorbic acid on DPPH radicals. A number of plants demonstrated either brine shrimp lethality or free radical scavenging activity.”
“SUNCT has been reported in association with abnormalities of the brainstem and pituitary region. We present a patient with a history of left optic nerve hypoplasia, mild hypothalamic-pituitary dysfunction, and SUNCT starting in adolescence. SUNCT with an early age of onset may be associated with congenital abnormality of the hypothalamic-pituitary axis.”
“Purpose
Locally advanced esophageal cancers are generally treated with neoadjuvant chemoradiotherapy,
followed by surgery in operable candidates. However, selleck products even if the patients were diagnosed as operable disease, surgery could not be performed on patients with poor condition or other comorbidity. In this case, definitive chemoradiotherapy (dCRT) is the other option for localized esophageal cancer. Therefore, the purpose of this study was to evaluate the efficacy and clinical prognostic factors for dCRT in locally advanced esophageal cancer.
Materials and Methods
We conducted GDC-0994 nmr a review of patients who received dCRT for locally advanced squamous esophageal cancer from 2004 to 2010, focusing on stages III and IVa. All patients received at least two cycles of platinum-based chemotherapy during radiation, and all tumor burdens were included in the radiation field. The treatment results were analyzed for patterns
of failure and prognostic factors associated with survival.
Results
In total, 63 patients were enrolled in this study. The overall response rate was 84.1%. Relief ABT-888 concentration from dysphagia after dCRT was achieved in 48 patients. The most frequent failure was local recurrence. The median overall survival (OS) was 23.0 months, and the 2-year survival rate was 45.4%. Similar results were observed for elderly study patients. Significant prognostic factors for OS were duration of smoking, high grade of dysphagia (score of 3 or 4), and shorter duration of progression-free and dysphagia-free survival. Maintenance chemotherapy after dCRT did not influence OS. However, “”good risk”" patients receiving maintenance chemotherapy showed better OS than those who did not receive maintenance chemotherapy (30.4 months vs. 12.0 months, p=0.002).
Conclusion
dCRT has a major role in improving survival and palliation of dysphagia in inoperable advanced esophageal cancer, even in elderly patients. Maintenance chemotherapy after dCRT may be effective in prolonging survival in “”good risk”" patients.”
“During our screening programme for agrochemicals from Chinese medicinal herbs, the root bark essential oil of Periploca sepium was found to possess strong contact toxicity against the fruit flies, Drosophila melanogaster with a LD50 value of 1.22 mu g/adult.