Widespread neural abnormalities, both morphological (Harrison 1999) and

functional (Minzenberg et al. 2009), have been reported in SZ in regions associated with executive function, such as prefrontal and parietal cortex (Perlstein et al. 2001; Callicott et al. 2003; Manoach 2003; Tan et al. 2007), and with reward processing, such as ventral striatum and midbrain (Juckel et al. 2006a,b; Jensen et Inhibitors,research,lifescience,medical al. 2008; Murray et al. 2008; Schlagenhauf et al. 2008; Waltz et al. 2009; Koch et al. 2010; Romaniuk et al. 2010). Understanding how neural abnormalities may disrupt the integration of information between executive function and the reward system Inhibitors,research,lifescience,medical Histone Demethylase pathway inhibitors offers a window into better understanding of the functional deficits in SZ. Decision making requires choosing between alternative behaviors that may require short-term sacrifice for long-term

gain, similar to choices in the laboratory delay-discounting (DD) task. The DD task requires a series of choices between receiving a small sooner (usually immediate) reward or a larger delayed reward (DR) (Rachlin et al. 1991; Green et al. 1996). Greater willingness to wait for larger but later rewards, or smaller DD, has been associated with less impulsivity (Ainslie 1975) and better cognition and executive function (Shamosh et al. 2008). Individuals with various addictions Inhibitors,research,lifescience,medical (Vuchinich and Simpson 1998; Bickel et al. 1999; Kirby et al. 1999; Mitchell 1999; Petry and Casarella 1999; Baker et al. 2003; Robles et al. 2011) and some psychiatric conditions (Crean et al. 2000; Petry 2001; Takahashi et al. 2008) show greater DD than controls do. Most studies using the DD paradigm characterize an individual’s Inhibitors,research,lifescience,medical choices by generating a discount function for him or her that models the effect of delay on subjective value of later rewards (e.g., Bickel et al. 1999; Heerey et al. 2007; Kirby et al. 1999). The parameter k is the rate at which an individual discounts future rewards,

Inhibitors,research,lifescience,medical with larger k’s indicating greater DD (Mazur and Coe 1987; Rachlin et al. 1991). However, few studies have systematically investigated choice or response consistency in DD. Consistency is highly relevant to SZ, Resminostat as many studies have noted that inconsistency of behavior and performance is one of the notable features of SZ (Cohen et al. 1999; Schooler et al. 2008). Often R2 has been used to index degree of consistency, that is, the correspondence between data points and a mathematical discounting model (for review and other methods of defining consistency, see Johnson and Bickel 2008). Previous behavioral studies of DD in SZ have yielded mixed results (Heerey et al. 2007, 2008, 2011; MacKillop and Tidey 2011; Wing et al. 2012; but see Ahn et al. 2011). Heerey and Gold (2007) and Heerey et al.