Tumors Selleckchem PCI-34051 with high Twist expression invaded deeper (P = 0.0044), had more lymph node metastasis (P = 0.038), had more distant nodal metastasis (P = 0.0073), had a more Crenolanib nmr advanced stage (P = 0.0011) and had more lymphatic invasion (P = 0.0011) than those that were low Twist expression. Table 1 Twist

and E-cadherin Selleck LY3023414 expression in relation to clinicopathological findings     Twist P E-cadherin P   Total ( n = 166) High Low   Preserved Reduced       n = 70 (40.2%) n = 96 (57.8%)   n =67 (40.4%) n =99 (59.6%)   Age   65.1 ± 9.0 63.7 ± 9.4 0.52 63.6 ± 9.8 64.8 ± 8.9 0.70 Sex                   Male 149 (89.8) 63 (90.0) 86 (89.6) 0.93 59 (88.1) 90 (90.9) 0.56     Female 17 (10.2) 7 (10.0) 10 (10.4)   8 (11.9) 9 (9.1)   Tumor location                   Upper 28 (16.9) 16 (22.9) 12 (12.5) 0.21 13 (19.4) 15 (15.2) 0.70     Middle 76 (45.8) 29 (41.4) 47 (49.0)   31 (46.3) 45 (45.5)       Lower 62 (37.4) 25 (35.7) 37 (38.5)   23 (34.3) 39 (39.4)   Histology                   Well 63 (38.0) 31 (44.3) 32 (33.3) 0.26 24 (35.8) 39 (39.4) 0.13     Moderate 76 (45.8) 27 (38.6) 49 (51.0)   36 (53.7) 40 (40.4)       Poor 27 (16.3) 12 (17.1) 15 (15.6)   7 (10.5) 20 (20.2)   pT                   pT1 46 (27.7)

10 (14.3) 36 (37.5) 0.0044 33 (49.3) selleck products 13 (13.1) <.0001     pT2 25 (15.1) 10 (14.3) 15 (15.6)   11 (16.4) 14 (14.1)       pT3 67 (40.4) 34 (48.6) 33 (34.4)   14 (20.9) 53 (53.5)       pT4 28 (16.9) 16 (22.9) 12 (12.5)   9 (13.4) 19 (19.2)   pN                   pN0 65 (39.2) 21 (30.0) 44 (45.8) 0.038 44 (65.7) 21 (21.2) <.0001     pN1 101 (60.8) 49 (70.0) 52 (54.2)   23 (34.3) 78 (78.8)   pM                   pM0 118 (71.1) 42 (60.0) 76 (79.2) 0.0073 58 (86.6) 60 (60.6) 0.0002     pM1 48 (28.9) 28 (40.0) 20 (20.6)   9 (13.4) 39 (39.4)   pStage                   I 30 (18.1) 7 (10.0) 23 (24.0) 0.0011 26 (38.8) 4 (4.0) <.0001     IIA 29 (17.5) 10 (14.3) 19 (19.8)   15 (22.4) 14 (14.1)       IIB 21 (12.7) 4 (5.7) 17 (17.7)   10 (14.9) 11 (11.1)       III 38 (22.9) 21 (30.0) 17 (17.7)   7 (10.5) 31 (31.1)       IV 48 (28.9) 28 (40.0) 20 (20.8)   9 (13.4) 39 (39.4)   Lymphatic invasion                   Positive 107 (64.5) 55 (78.6) 52 (54.2) 0.0010 33 (49.3) 74 (74.8) 0.0008     Negative 59 (35.5) 15 (21.4) 44 (45.8)   34 (50.8) 25 (25.3)   Venous invasion                   Positeive 51 (30.7) 26 (37.1) 25 (26.0) 0.13 17 (25.4) 34 (34.3) 0.22     Negative 115 (69.3) 44 (62.9) 71 (74.0)   50 (74.6) 65 (65.