This will enable definitions of worldwide criteria for the timing of emergency surgery. When dealing with surgical emergencies, descriptive words for “timely surgery” should be substituted with unambiguous and reproducible time frames. This needs to be scrutinized, tested and validated on a worldwide scale. In an effort to understand current occurrence in acute care of surgical emergencies and common practices of emergency surgery scheduling, WSES panel experts were asked to assign iTTS to

a number of common surgical emergencies – acute appendicitis, incarcerated inguinal hernia, mesenteric ischemia, perforated duodenal ulcer and peri- anal abscess. The results are summarized in Table 2. The TACS study identified high agreement among responders regarding the time frame learn more presented for common surgical emergencies. Although the data presented in the table does not concur with current views in the literature regarding some of the clinical entities surveyed, this may reflect availability of operating theaters in some of the institutions participating in the study. In most institutions, scheduling of unplanned is a matter of dialogue and negotiation where dedicated operating theaters are not assigned for surgical emergencies. The discrepancy revealed in iTTS assessment between JPH203 in vivo TACS respondents

and the current literature, e.g. timing of appendectomy [3] and cholecystectomy [5], indicate that further

studies are needed to establish iTTS for surgical emergencies. Until this is accomplished a certain frame of iTTS can be proposed and implemented as an interim guideline for the timing of surgical interventions in surgical emergencies as proposed in Figure 1. Figure 1 Proposed Ideal Time to Surgery (iTTS) and color coding. Table 2 Expert opinion on timing of surgery in common surgical emergencies   n-43(%) Immediate Surgery   Mesenteric Event 37 Cytidine deaminase (86) Evisceration 27 (62.8) Hemodynamic Instability due to bleeding 42 (97.7) Surgery Within an Hour   Incarcerated Hernia 35 (83.3) Perforated Viscus 35 (83.3) Necrotizing Fasciitis* 34 (79.1) Surgery Within 6 Hours   Soft Tissue Infection (Abscess) 37 (86) Appendicitis* 36 (83.7) Cholecystitis* 29 (67.4) Surgery Within 24–48 Hours   Second Look Laparotomy 41 (95.3) *expert opinion not in aptness with current literature. The National Confidential Enquiry into Patient Outcome and Death (NCEPOD) in the United Kingdom classifies interventions as immediate, urgent, expedited and elective [14]. For each of these categories, the respective target times to theatre from decision to operate is within minutes, hours, days or planned. There is general agreement that cases requiring immediate attention will be triaged before less urgent cases. Cases classified between these two groups raise the greatest debate in terms of patient Volasertib priority.