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“This article evaluates the authors’ own concept of integrated IT environments for people with disabilities. Increasing numbers of disabled people and elderly people are affected by shortages of medical specialists and limited funding for medical care. Integrated IT environments for people with disabilities – through integration of various technical and medical solutions into one flexible system – are one way to provide increased independence and improved quality of life for disabled, elderly and severely ill people. The aim of this paper is to assess

the extent to which the available possibilities in this area are being utilized, including the authors’ own concept. The implications of technological developments are discussed to lay the groundwork for further research.”
“Purpose of review

Infections AG-881 GSK2879552 inhibitor due to nontuberculous mycobacterial (NTM) infections are increasing and, thus, it is likely that practitioners will see an increase in NTM infections in transplant recipients.

Recent findings

There have been few recent comprehensive studies evaluating the epidemiology, diagnosis, and treatment of NTM infections in transplant recipients. Most recent studies have reported unusual and interesting manifestations of NTM infection. Other studies have described the posttransplant outcomes of patients

with pretransplant cultures that grew NTM and provided recommendations regarding the appropriateness of performing transplants in these patients.

Summary

Recent studies have documented the protean nature of the clinical presentation of NTM infections in transplant recipients. These studies, as well as previously published reports, highlight the

need for a high index of suspicion for clinicians when managing transplant patients with unexplained fever, cutaneous lesions, joint infections, or radiographic opacities. Early diagnosis of NTM infection and initiation of therapy are needed to prevent morbidity and mortality in this vulnerable population.”
“Gastric neuroendocrine neoplasia has been classified as neuroendocrine tumor (NET), selleck compound a less-malignant type, and neuroendocrine carcinoma (NEC), a more-malignant type. We investigated phenotypic expression profiles to clarify the differences between NET and NEC in terms of histopathology and carcinogenesis.

We assayed 86 cases of gastric neuroendocrine neoplasms (NET G1, n = 25; NET G2, n = 9; NEC, n = 52), using six exocrine markers (MUC5AC, human gastric mucin, MUC6, M-GGMC-1, MUC2, and CDX2).

NEC frequently coexisted with adenocarcinomatous components (75 %; 39 of 52) and the majority (71.8 %; 28 of 39) showed intraglandular endocrine cell hyperplasia, although no cases of NET showed adenocarcinomatous components. Mucin phenotype significantly differed between NET and NEC; none of NET cases expressed any exocrine markers other than CDX2, although the majority of NEC (86.5 %; 45 of 52) expressed at least one or more exocrine markers with various positive rates for each marker (range, 8.2-74.0 %).