The results suggest that liraglutide might be a treatment option for type 2 diabetes, especially when weight loss and risk of hypoglycaemia are major considerations.”
“OBJECTIVE: There is significant debate in the literature regarding the optimal management of patients with the diagnosis of a spinal epidural abscess (SEA). Although some have advocated conservative treatment with intravenous antibiotics alone in select patients, recent studies have shown that patients treated without early surgery

selleck compound are more likely to have poor outcomes.

METHODS: In this study, we review patients treated at a tertiary medical center with a spontaneous SEA. A total of 104 patients had a diagnosis of an SEA over a 10-year period. More than half of these patients presented with back pain alone and no

objective motor weakness. Sixty-four patients (61.5%) were treated conservatively with computed tomography-guided aspiration or antibiotics alone based on blood cultures, whereas 40 patients (38.5%) underwent surgical decompression.

RESULTS: Of the patients managed nonoperatively, 11% improved, 64% remained stable, and 17% died. Conversely, of the patients treated with surgery, 25% improved, 43% remained stable, and 23% died. Review of the imaging studies revealed that 65.4% of patients had a ventral SEA, whereas 34.6% had a dorsal SEA. Although there were no statistically significant differences between these 2 groups in terms of management Or outcome, 30.6% of click here the patients with a dorsal SEA were paraplegic or quadriplegic, and only 7.30% of the patients with a ventral SEA were paraplegic or quadriplegic (P = 0.003).

CONCLUSION: Our data do not support the hypothesis that patients treated without early surgery are more likely to have a poor outcome. Furthermore, we propose that the anatomy of the SEA (ventral or dorsal) should play an important role in determining the treatment plan.”
“Background Placental-site Adenosine triphosphate trophoblastic tumours are a rare form of gestational trophoblastic disease and consequently information about optimum management or

prognostic factors is restricted. We aimed to assess the long-term outcome of stage-adapted management by surgery, chemotherapy, or both for patients with the disorder.

Methods 35550 women were registered with gestational trophoblastic disease in the UK (1976-2006), of whom 62 were diagnosed with placental-site trophoblastic tumours and included, retrospectively, in the study. Patients were treated by surgery, chemotherapy, or both. We estimated the probabilities of overall survival and survival without recurrence of disease 5 and 10 years after the date of first treatment, and calculated the association of these endpoints with prognostic factors, including time since antecedent pregnancy, serum concentration of beta-human chorionic gonadotropin, and stage of disease, with both univariate and multivariate analyses.