It’s perhaps not surprising that these substances have different pharmacological properties than the amides or even the esters where they’re derived. From this point of view the inhibition of cyclooxygenases, Ivacaftor CFTR inhibitor especially COX2, might have many influences at the level of central nervous system or in immune cells. The products of endocannabinoids were reviewed elsewhere and will not create a matter for this paper. The cannabinoid receptors and endocannabinoids The human cannabinoid receptor 1 was cloned by Gerrard et al.. CB1 receptors are coupled with Gi/Go proteins and are serpentine receptors. Through G-protein action the experience of adenylyl cyclase is diminished, that leads to a loss of cAMP level. The activity of some ionic channels can be modulated. The human cannabinoid receptor 2 was initially identified in man in 1993. CB2 receptors are coupled with Gi/Go type proteins. Unlike CB1 receptors, the CB2 types do not appear to be coupled to ionic channels. They’re along with intracellular signalization paths related to MAP kinase. Still another two serpentine receptors, labeled among orphan receptors because, Cellular differentiation when found, there did not exist a particular ligand to bind them, are said to be cannabinoid receptors. These two receptors remain named GPR55 and GPR119. Still another receptor for anandamide could be the transient receptor potential vanilloid1 receptor, the receptor for capsaicin. Anandamide and particularly 2 arachidonoyl glycerol could function as retrograde synaptic messengers. They are produced from postsynaptic neurons and travel backward across synapses, triggering CB1 on presynaptic axons and controlling neurotransmitter release. Cannabinoids may influence pain perception, knowledge, and memory in the form of this mechanism. Endogenous ligands for CB receptors identified so far are eicosanoids: N arachidonoylethanolamide, Hedgehog inhibitor 2 arachidonoyl glycerol, noladin ether, Oarachidonoylethanolamine and Narachidonoyldopamine. Anandamide, 2 arachidonoyl glycerol, and Narachidonoyldopamine are susceptible to degradation by fatty acid amide hydrolase, although an additional enzyme, monoacylglycerol lipase, catalyzes hydrolysis of 2 arachidonoylglycerol in vivo. Numerous chemicals with cannabinoid properties were defined. They might act as complete or partial agonists, antagonists or inverse agonists, natural antagonists, or may possibly boost the level. Many of them are presented in table I. Cyclooxygenases inhibitors or nonsteroidal antiinflammatory drugs are a heterogeneous number of chemicals that block either the cyclooxygenase site of enzyme cyclooxygenase form 1 or 2, or its peroxidase site. In the first category may be mentioned ibuprofen, diclofenac, indomethacin, coxibs and in the 2nd category might be included acetaminophen and metamizole sodium.