However, the definition and pathogenesis of MetS are still debated, and no standardized definition nor proven prognostic value learn more has been established for MetS as a cluster of risk factors for diabetes or cardiovascular disease in PD patients. Furthermore, considering the paradoxical associations of some of the risk factors in MetS with decreased mortality, another set of risk factors-those specific to patients with
uremia (for example, inflammation and malnutrition)-and the appropriate cut-off levels to individual MetS risk factors should be taken account at the same time. Also, the benefit of interventions targeting these risk factors should be clarified in further clinical studies.”
“This study investigated the effect of a 3-month treatment with Withania somnifera on apoptosis and intracellular reactive oxygen species (ROS) concentration of spermatozoa and the metal ions copper, zinc, iron and gold in seminal plasma from infertile men (normozoospermic, n = 25; oligozoospermic, n = 25; and asthenozoospermic, n = 25). The apoptotic and necrotic cell distribution were analysed by annexin-V binding and propidium iodide uptake using flow cytometry. ROS generation was measured by fluorescence intensity and metal ions were analysed by atomic absorption
spectrophotometry. The results https://www.selleckchem.com/products/kpt-8602.html demonstrated that, prior to treatment, sperm apoptosis and check details intracellular ROS concentrations were significantly higher
in all groups of infertile men compared with controls (P < 0.01 to P < 0.001). Similarly, the concentrations of the essential metal ions Cu2+, Zn2+, Fe2+ and Au2+ in seminal plasma were lower. Treatment with W. somnifera significantly reduced apoptosis in normozoospermic and oligozoospermic men and ROS concentrations in oligozoospermic and asthenozoospermic men (all P < 0.05). Treatment also significantly improved metal ion concentrations in infertile men (P < 0.01). It is concluded that W. somnifera improves semen quality by reducing oxidative stress and cell death, as well as improving essential metal ion concentrations. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“Objective(s): We sought to establish the relationship between maternal mid-trimester heart rate (HR) and neonatal birth weight in women at high a priori risk of preeclampsia.
Study Design: Ninety-nine women were recruited following second trimester uterine artery Doppler assessment. Maternal blood pressure (BP) and HR were measured between 23(+4) and 30(+5) weeks gestation and neonatal birth weight was expressed as a z-score. The relationship between the parameters was investigated using Pearson’s correlation coefficient.
Results: There was a significant positive correlation between maternal HR and neonatal birth weight z-score, r = 0.22 (95% CI: 0.02-0.40), p = 0.03.