Figure 2Evolution of mean arterial pressure (MAP) during the first 24 hours. The evolution of hourly MAP (left panels) and of MAP time-averaged MAP (right panels) compared between patients Idelalisib solubility who will have acute kidney insufficiency (AKI) at H72 (black squares) …Figure 3Mean arterial pressure (MAP) according to the presence or not of septic shock. The MAP (from H6 to H24 for hourly MAP and for time-averaged MAP) was significantly lower in patients who will than in those who will not have AKI at H72 in the septic shock …Figure 4Mean arterial pressure (MAP) according to the presence of septic shock or acute kidney insufficiency. The MAP (from H6 to H24 for hourly MAP and for time-averaged MAP) was significantly lower in patients who will than in those who will not have AKI at …

Table Table33 shows the AUCs for time-averaged MAP to predict AKI at H72 in the different groups of patients. It appears that time-averaged MAP predicted AKI at H72 with good discriminative power only in the sub-group of patients with AKI at H6 and septic shock. In this sub-group time-averaged MAP over H6 to H24 yielded an AUC of 0.83 (0.72 to 0.92) associated with a sensitivity of 0.72 and specificity of 0.87. The best cut-off value of time-averaged MAP over H6 to H24 was 72 mmHg, which was also the highest value associated with a positive LR > 5 (5.5 (4.2 to 7.2)). The lowest value of time-averaged MAP over H6 to H24 associated with a negative LR < 0.2 was 80 mmHg (negative LR = 0.16 (0.04 to 0.6), sensitivity = 0.92 (0.74 to 0.99), specificity = 0.50 (0.33 to 0.67)).

In the same sub-group of patients time-averaged MAP over H12 to H24 yielded an AUC of 0.84 (0.72 to 0.92) associated with a sensitivity of 0.78 and specificity of 0.89. The best cut-off value of time-averaged MAP over H12 to H24 was 72 mmHg, which was also the highest value associated with a positive LR > 5 (6.0 (4.6 to 7.6)). The lowest value of time-averaged MAP over H12 to H24 associated with a negative LR < 0.2 was 82 mmHg (negative LR = 0.19 (0.05 to 0.8), sensitivity = 0.92 (0.74 to 0.99), specificity = 0.50 (0.33 to 0.67)). Figure Figure55 shows the different AUCs of time-averaged MAP over H6 to H24 or over H12 to H24 Batimastat to predict AKI at H72 in the four sub-groups of patients according to the presence or not of AKI at H6 and of septic shock.Table 3Discriminative power of mean arterial pressure to predict acute kidney insufficiency at H72Figure 5Performance of mean arterial pressure to predict acute kidney insufficiency (AKI) at H72. The areas under the receiver operating characteristics curves (AUC) of time-averaged MAP over H6 to H24 (left panel) and over H12 to H24 (right panel) to predict …