As many now have come to reassess their approach to the management of GDM, we provide information in this review to help guide this process. The goal for each health care practitioner should continue to be to provide optimum care for women discovered to have carbohydrate intolerance during pregnancy. (Obstet Gynecol 2011;118:1379-93)
DOI: 10.1097/AOG.0b013e31823974e2″
“Linum usitatissimum (Linn.), commonly known as flaxseed, which is a good source of dietary fiber and lignans. Secoisolaricirecinol diglucoside (SDG) from flaxseed and omega-3 fatty acids (n-3-FA) from algal source have been shown to have multiple health benefits including cardiovascular disorders and related disorders. The objective of present study was to prepare methanolic fraction of flax lignan concentrate (MF-FLC) and to investigate the antihyperlipidemic see more activity of MF-FLC and omega-3-fatty acid alone and in Selleck ABT 737 combination after acute administration in poloxamer-407 induced hyperlipidemic rats. Solvent-solvent extraction method revealed around 3 times increase in SDG lignan content than that of flax lignan concentrate. Acute hyperlipidemia was induced in rats using poloxamer
407 (1 ml of 30%, w/v; i.p.). Concomitant administration of MF-FLC (100 mg/kg) and n-3-FA (1 ml/kg) significantly reduced serum cholesterol (p < 0.001), triglyceride (p < 0.001) and very low density lipoprotein (p PF-03084014 < 0.001) whereas high density lipoprotein showed significant increase (p < 0.05). It can be concluded that supplementation of MF-FLC and n-3-FA can be useful for prevention/control of hyperlipidemia. (C) 2013 Elsevier B.V. All rights reserved.”
“Purpose of review
Four new therapies have been recently approved for the treatment of men with castration-resistant prostate cancer; still, more treatment options are
needed. This review summarizes the data supporting a role for novel chemotherapies including epothilones and immunomodulators (IMiDs), as well as other novel agents within the new landscape of approved therapies.
Recent findings
Epothilones are a class of chemotherapy that target microtubule disassembly, similar to taxanes. Results from phase II studies demonstrating a positive impact on serum prostate-specific antigen for patupilone and sagopilone, current epothilones in development, along with those of ixabepilone, are comparable with historical response rates to docetaxel, the current first-line chemotherapy for castration-resistant disease. IMiDs, including lenalidamide and thalidomide, are also in active development in castration-resistant prostate cancer. A recent phase III study evaluating the combination of lenalidomide and docetaxel revealed decreased overall survival relative to docetaxel alone; however, additional trials are currently recruiting to investigate lenalidomide in various other combination regimens.