465 0 04 −0 03–0 11 0 298 0 00 −0 08–0 08 0 985 Model 2 Maternal

465 0.04 −0.03–0.11 0.298 0.00 −0.08–0.08 0.985 Model 2 Maternal smokinga 0.05 −0.04–0.13 0.277 0.04 −0.04–0.12 0.369 0.06 −0.03–0.16 0.194 Paternal smoking 0.02 −0.05–0.09 0.588 0.03 −0.04–0.10 0.409 −0.01 −0.08–0.07 0.894 Model 3 Maternal smokinga 0.00 −0.04–0.05 0.925 0.00 −0.04–0.03 0.845 0.02

−0.05–0.10 0.523 Paternal smoking −0.02 −0.06–0.02 0.383 −0.01 −0.04–0.02 0.644 −0.03 −0.10–0.03 0.266 Girls TBLH BMC (SD score: 1 SD = 191.5 g) TBLH BA (SD score: 1 SD = 172.3 cm2) TBLH BMD (SD score: 1 SD = 0.055 g/cm2) Maternal smoking in any trimester Model 1 0.13 0.05–0.22 0.003 0.13 0.04–0.21 0.004 0.13 0.04–0.22 0.005 Model 2 0.17 0.08–0.25 <0.001 0.17 0.08–0.25 <0.001 0.15 0.06–0.24 0.001 Model 3 0.02 −0.02–0.06 0.384 0.02 −0.01–0.06 0.205 0.02 −0.04–0.08 0.528 Maternal smoking in all trimesters

Model 1 0.15 0.03–0.26 0.011 0.15 0.04–0.26 0.009 0.13 0.01–0.24 0.037 Model 2 0.20 0.09–0.32 0.001 0.21 0.10–0.32 <0.001 0.16 0.04–0.28 0.008 www.selleckchem.com/mTOR.html https://www.selleckchem.com/products/azd5153.html Model 3 0.02 −0.03–0.07 0.371 0.03 −0.01–0.08 0.127 0.01 −0.07–0.09 0.871 Paternal smoking Model 1 0.15 0.08–0.22 <0.001 0.14 0.08–0.21 <0.001 0.14 0.07–0.21 <0.001 Model 2 0.16 0.09–0.23 <0.001 0.15 0.09–0.22 <0.001 0.15 0.07–0.22 <0.001 Model 3 0.03 −0.00–0.07 0.058 0.03 0.00–0.06 0.029 0.04 −0.02–0.09 0.164 Combined models Model 1 Maternal smokinga 0.10 0.01–0.19 0.025 0.10 0.01–0.19 0.030 0.10 0.01–0.19 0.032 Paternal smoking 0.12 0.05–0.20 0.001 0.12 0.05–0.19 0.002 0.12 0.04–0.19 0.004 Model 2 Maternal smokinga 0.13 0.04–0.22 0.004 0.13 0.04–0.22 0.003 0.12 0.03–0.21 0.011 Paternal smoking 0.12 0.05–0.19 0.001 0.12 0.05–0.19 0.001 0.11 0.04–0.19 0.004 Model 3 Maternal smokinga 0.01 −0.03–0.05 0.670 0.01 −0.02–0.05 0.457 0.01 −0.05–0.08 0.706 Paternal smoking 0.03 −0.01–0.06 0.101 0.03 −0.00–0.06 0.087 0.04 −0.02–0.10 0.198 Model 1 is adjusted for the child’s age, mother’s parity, household social class and maternal/paternal

factors (age, height, pre-pregnancy BMI, education). Model 2 is adjusted Rabusertib clinical trial additionally for the child’s gestational age and birth weight Model 3 is adjusted for all these plus the child’s height and weight at age 9.9 years Reference category Orotidine 5′-phosphate decarboxylase for maternal smoking variables is “Never smoked during pregnancy” and for paternal smoking variable is “Non-smoking” BA bone area, BMC bone mineral content, BMD bone mineral density, TBLH total body less head aMaternal smoking in any trimester Table 3 Sex-specific associations of maternal and paternal smoking with spinal bone outcomes at age 9.9 years in multiple imputation analysis (boys N = 2,772; girls N = 2,715)   Mean difference 95% CI P value Mean difference 95% CI P value Mean difference 95% CI P value Boys Spine BMC (SD score: 1 SD = 14.8 g) Spine BA (SD score: 1 SD = 11.7 cm2) Spine BMD (SD score: 1 SD = 0.076 g/cm2) Maternal smoking in any trimester Model 1 0.03 −0.06–0.12 0.501 0.00 −0.09–0.09 0.918 0.05 −0.04–0.14 0.304 Model 2 0.07 −0.02–0.16 0.153 0.05 −0.04–0.14 0.289 0.07 −0.03–0.16 0.171 Model 3 0.01 −0.05–0.07 0.683 0.01 −0.04–0.

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