0004). Interestingly, in terms of VDR we found Selleckchem GSK3326595 a shift to a more mixed nuclear/cytoplasmic staining in the HPT group compared to normal parathyroid gland cells, which showed solitary nuclear staining for VDR (p > 0.05). Conclusions: CaSR, VDR and an impaired Klotho-FGFR-axis seem to be the major players in the development of sHPT. Whether the detected correlation between FGFR and VDR and the shift to a more mixed nuclear/cytoplasmic staining of VDR will yield new insights into the pathogenesis of the disease has to be evaluated in

further studies. Copyright (c) 2013 S. Karger AG, Basel”
“There is agreement in that strengthening the sets of neurobiological data would reinforce the diagnostic objectivity of many psychiatric entities. This article attempts to use this approach in borderline personality disorder (BPD). Assuming that most of the biological findings in BPD reflect common underlying pathophysiological processes we hypothesized that most of the data involved in the selleck chemicals findings would be statistically interconnected and interdependent, indicating biological consistency for this diagnosis. Prospectively obtained data on scalp and sleep electroencephalography

(EEG), clinical neurologic soft signs, the dexamethasone suppression and thyrotropin-releasing hormone stimulation tests of 20 consecutive BPD patients were used to generate a Bayesian network model, an artificial intelligence paradigm that visually illustrates eventual associations (or inter-dependencies) between otherwise seemingly unrelated variables. learn more The Bayesian network model identified relationships among most of the variables. EEG and TSH were the variables that influence most of the others, especially sleep parameters. Neurological soft signs were linked with EEG, TSH, and sleep parameters. The results suggest the possibility of using objective neurobiological variables to strengthen the validity of future diagnostic criteria and nosological characterization of BPD. (C) 2010 Elsevier Ireland Ltd. All rights

reserved.”
“To the Editor: Myburgh and Mythen (Sept. 26 issue)(1) suggest that it is difficult to justify using semisynthetic colloid solutions for fluid resuscitation in critically ill patients. However, although the adverse effects of colloids have been clearly shown, information on potential benefits remains sparse. Colloids are frequently used for resuscitation of patients with dengue shock syndrome, a potentially fatal complication of dengue characterized by substantial plasma leakage and hypovolemic shock.(2),(3) At our hospital in Ho Chi Minh City, more than 200 children or young adults are admitted annually with dengue shock syndrome, of whom approximately 30 to 40% require …”
“Exposure to the wide variety of chemicals used for manufacturing consumer products commonly occurs daily and the consequences to health are beneficial.