3) and that ��Addiction treatment facilities and programs are not adequately regulated or held accountable for providing treatment consistent with medical EPZ-5676 leukemia standards and proven treatment practices.�� (National Center on Addiction and Substance Abuse at Columbia University Inhibitors,Modulators,Libraries 2012, pp. 3�C4). The current addiction treatment system first was conceptualized in the middle of the last century, as documented by White (2002), and has changed little since. No other chronic disease is treated with brief stints in a program with limited follow up care. Instead, for other chronic conditions patients are followed closely by physicians and other professionals over long periods of time, with the goal of minimizing symptoms and relapses, treating complications, and maximizing function.

In these cases, care is provided indefinitely, often for life. Such a longitudinal-care approach also offers considerable promise in treating people with severe recurrent alcohol dependence. Several studies Inhibitors,Modulators,Libraries have found a highly significant positive effect for longitudinal care in people who have one or more medical complications of alcohol dependence (Kristenson et al. 1984; Lieber et al. 2003), including two studies that found significant reduction Inhibitors,Modulators,Libraries in 2-year mortality (Willenbring and Olsen 1999; Willenbring et al. 1995). Some findings also indicate that integrating treatment for substance use disorders into that for severe and persistent mental illness may be effective at reducing substance use, although no high-quality randomized controlled trials of this Inhibitors,Modulators,Libraries approach have been published (Drake et al. 2006).

Pharmacotherapy for AUDs also may be effective in people with severe mental illnesses (Petrakis et al. 2004, 2005, 2006; Salloum et al. 2005). Finally, the ongoing need for recovery support and maintenance should be addressed. Thus, more research is needed on the best long-term Inhibitors,Modulators,Libraries management strategies for recurrent alcohol dependence. Conclusion At this time no solid conclusions can be drawn as to whether current approaches to prevention of and treatment for AUDs reduce the disease burden attributable to heavy drinking, although these strategies have shown positive outcomes in the short term. SBI for at-risk drinkers in ambulatory primary care settings has the strongest evidence for efficacy, and some evidence supports its cost-effectiveness and associated reduction in excess morbidity and dysfunction.

However, these benefits do not necessarily indicate that health care costs for these patients are reduced. Widespread implementation of SBI for nondependent heavy drinkers outside of Cilengitide the medical context has the potential to have a large public health impact. For heavy drinkers with more severe conditions (i.e., recurrent alcohol dependence), time-limited counseling may improve short-term recovery rates, but its long-term impact is less clear.